Long-term effects on testicular function of high-dose testosterone treatment for excessively tall stature
作者： B Lemcke , J Zentgraf , H M Behre , S Kliesch , J H Bramswig
DOI: 10.1210/JCEM.81.1.8550767
关键词: Semen 、 Semen analysis 、 Reproductive medicine 、 Hormone 、 Varicocele 、 Tall Stature 、 Internal medicine 、 Testosterone 、 Sperm 、 Medicine 、 Endocrinology
摘要: High-dose testosterone treatment is applied during puberty to reduce the predicted adult height in excessively tall boys. To date it has remained unclear whether this therapy produces any long-term effects on reproductive functions of patients. clarify question, we performed a follow-up study 47 men, determining seminal and hormonal parameters 10.6 +/- 2.5 years (mean SD) after cessation therapy. The men treated were compared with 123 normal attending Institute Reproductive Medicine as volunteers for various clinical studies. Clinical examination revealed significantly higher prevalence varicoceles history maldescended testes testosterone-treated controls. Semen analysis lower progressive motility (49.2 13.4 vs. 54.3 12.8%). A nonsignificant tendency towards sperm concentration (43.8 35.4 57.8 45.6 mL/mL), total c...
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