Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients.
作者： Marianne Nordsmark , Jesper Grau Eriksen , Val Gebski , Jan Alsner , Michael R. Horsman
DOI: 10.1016/J.RADONC.2007.04.021
关键词: Radiation therapy 、 Medicine 、 Internal medicine 、 Hypoxia (medical) 、 Pathology 、 Osteopontin 、 Oncology 、 Nimorazole 、 Predictive marker 、 Head and neck cancer 、 Stage (cooking) 、 Radiosensitizer
摘要: Purpose: Hypoxia adversely relates with prognosis in human tumours. Five hypoxia specific predictive marker assays were compared and correlated definitive radiotherapy. Patients methods: Sixty-seven patients advanced head neck carcinomas studied for pre-treatment plasma osteopontin measured by ELISA, tumour oxygenation status using pO2 needle electrodes osteopontin, inducible factor 1a (HIF-1a) carboxyanhydrase 9 (CA9) immunohistochemistry. The primary treatment was radiotherapy the hypoxic radiosensitizer nimorazole. Loco-regional control evaluated at 5 years. Results: All five markers showed inter-tumour variability. Inter-marker correlations inconsistent. Only inversely median ,( p = 0.02, r 0.28) CA9 HIF-1a (p < 0.01, 0.45). In Kaplan‐Meier analysis high proportion of 6 2.5 mm Hg (HP2.5) related significantly poorer loco-regional control, whereas failed to predict this set dataset. When analyzing Hb, stage, competing risks HP2.5 strongest variable control. Conclusion: There diversity lack correlation among different within individual High OPN local c 2007 Elsevier Ireland Ltd. rights reserved. Radiotherapy Oncology 83 (2007) 389‐397.
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