Multi-marker RT-PCR panel for detecting metastatic breast cancer
作者： David J. Cole , Paul H. O'Brien , Paul L. Baron
DOI:
关键词: Pathology 、 Primary tumor 、 Nucleic acid 、 Lymph node 、 Cancer 、 Biology 、 Histopathology 、 Metastasis 、 Real-time polymerase chain reaction 、 Metastatic breast cancer
摘要: A method of detecting the metastasis primary breast cancer to a lymph node is provided, comprising detecting, in tissue, presence nucleic acid c-myc, PIP or keratin-19. The any one these acids tissue associated with metastatic cancer. more markers other indicates that cells from tumor have migrated tissue. Also provided predicting histopathologic stage patient without having perform analysis, patient, c-myc being correlated I as determined by histopathology. Alternatively, absence and keratin-19 are In another embodiment, stages later than Further, survival time patients also shorter average compared none acids.
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