A novel approach for selective brain cooling: implications for hypercapnia and seizure activity
作者： Hubert Trübel , Peter Herman , Christoph Kampmann , Ralf Huth , Paul K. Maciejewski
DOI: 10.1007/S00134-004-2350-1
关键词: Medicine 、 Bicuculline 、 Intensive care 、 Central nervous system disease 、 Central nervous system 、 Epilepsy 、 Hypercapnia 、 Anesthesia 、 Cortex (botany) 、 Respiratory system
摘要: During selective brain cooling (SBC) the temperature (TB) is reduced while core (TC) remains unchanged. This animal study investigated changes in induced by a novel approach of from pharynx (pSBC) and whether these are related to commonly encountered clinical situations (i.e., seizure activity hypercapnia). Experimental study. Male Sprague-Dawley rats. pSBC was achieved heat exchanger placed pharynx; hypercapnia were adding CO2 respiratory gases intravenous injection bicuculline, respectively. TB, TC, (TP) measured continuously with thermocouples. TB declined significantly 36.9±0.67°C 33.1±1.23°C. There trend towards lower TC during (from 36.9±0.70 36.4±1.2°C). TP 29.1±2.19°C. From lowest rose challenge 1.22±0.67°C (vs. 0.85±0.34°C non-SBC controls). 2.08±0.35°C 1.15±0.55°C Significant cortex can be rat rodent model. Marked increases observed. These results may have implications for methods settings. For example, offer distinct advantages over alternative such as whole-body externally implemented SBC.
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sci-hub.se 参考文章(19)
Derk W. Krieger, Michael A. De Georgia, Alex Abou-Chebl, John C. Andrefsky, Cathy A. Sila, Irene L. Katzan, Marc R. Mayberg, Anthony J. Furlan, Cooling for Acute Ischemic Brain Damage (COOL AID): An Open Pilot Study of Induced Hypothermia in Acute Ischemic Stroke Stroke. ,vol. 32, pp. 1847- 1854 ,(2001) , 10.1161/01.STR.32.8.1847
Raymond M. Quock, Richard W. Panek, F.Jay Kouchich, M.A. Rosenthal, Nitrous oxide-induced hypothermia in the rat. Life Sciences. ,vol. 41, pp. 683- 690 ,(1987) , 10.1016/0024-3205(87)90447-4
Katherine V. Biagas, Mary Lou Gaeta, Treatment of traumatic brain injury with hypothermia. Current Opinion in Pediatrics. ,vol. 10, pp. 271- 277 ,(1998) , 10.1097/00008480-199806000-00009
D. A. Nelson, S. A. Nunneley, Brain temperature and limits on transcranial cooling in humans: quantitative modeling results European Journal of Applied Physiology. ,vol. 78, pp. 353- 359 ,(1998) , 10.1007/S004210050431
Marianne Thoresen, Martin Simmonds, Saulius Satas, James Tooley, Ian A Silver, Effective Selective Head Cooling during Posthypoxic Hypothermia in Newborn Piglets Pediatric Research. ,vol. 49, pp. 594- 599 ,(2001) , 10.1203/00006450-200104000-00024
Tania R. Gunn, Nigel J. Wilson, Salim Aftimos, Alistair J. Gunn, Brain Hypothermia and QT Interval Pediatrics. ,vol. 103, pp. 1079.1- 1079 ,(1999) , 10.1542/PEDS.103.5.1079
Stephen A. Bernard, Timothy W. Gray, Michael D. Buist, Bruce M. Jones, William Silvester, Geoff Gutteridge, Karen Smith, Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia The New England Journal of Medicine. ,vol. 346, pp. 557- 563 ,(2002) , 10.1056/NEJMOA003289
Clifton W. Callaway, Scott C Tadler, Laurence M Katz, Christopher L Lipinski, Eric Brader, Feasibility of external cranial cooling during out-of-hospital cardiac arrest Resuscitation. ,vol. 52, pp. 159- 165 ,(2002) , 10.1016/S0300-9572(01)00462-2
M.R. Zarrindast, Y. Oveissi, GABAA and GABAB receptor sites involvement in rat thermoregulation General Pharmacology: The Vascular System. ,vol. 19, pp. 223- 226 ,(1988) , 10.1016/0306-3623(88)90065-1
Alejandro Flores-Maldonado, Carolina E Medina-Escobedo, Hugo M.G Rı́os-Rodrı́guez, Ramón Fernández-Domı́nguez, Mild Perioperative Hypothermia and the Risk of Wound Infection Archives of Medical Research. ,vol. 32, pp. 227- 231 ,(2001) , 10.1016/S0188-4409(01)00272-7