Hepatitis E virus infection in a cohort of patients with acute non-A, non-B hepatitis

摘要: Abstract Background/Aims: The aim of this study was to determine the frequency hepatitis E virus infection in a cohort patients with acute non-A, non-B Greece. Methods: Serial serum samples 198 and single specimen from 316 healthy subjects were tested for IgG IgM antibodies (anti-HEV). Results: Anti-HEV found 15198 (7.6%) 7316 (2.2%) controls ( p =0.007). 2198 (1.0%) none subjects. Neither anti-HEV (+) case reported any risk factor neither had travelled areas endemic infection. HEV-RNA detected by reverse transcription polymerase chain reaction one patient. prevalence 745 (15.6%), 146 (2.2%), 530 (16.7%) 277 (2.6%) reporting transfusion, intravenous drug use, occupational/hospitalization, unknown transmission, respectively 13122 (10.7%) 276 positive negative anti-HCV, =0.03). A similar association anti-HBc significantly higher cases transfusion [OR=7.3, 95% C.I. 1.4–37.7, =0.017] occupational/hospitalization [OR=6.8, 1.2–38.2, =0.029], as transmission category after controlling age. Conclusions: These findings indicate that: (a) may be cause - although not frequent sporadic or community-acquired Greece; (b) share routes B C viruses; (c) hypothesis that transmitted parenteral deserves careful consideration.