Antihyperalgesic and antiedematous activities of bisabolol-oxides-rich matricaria oil in a rat model of inflammation.

摘要: From the dried flower heads of Matricaria recutita L., essential oil was isolated by hydrodistillation, and in obtained blue oil, α-bisabolol oxide A (21.5%), B (25.5%) (Z)-spiroether (cis-en-yn-spiroether) (10.3%) were identified as main compounds, gas chromatography (GC) GC–mass spectrometry analyses. The antihyperalgesic effects this examined a rat model inflammation induced carrageenan, through modified ‘paw-pressure’ test. Antiedematous dextran histamine, plethysmometry. (25, 50 100 mg/kg, p.o.) exhibited significant dose-dependent reduction hyperalgesia edema carrageenan both prophylactic therapeutic treatment schemes. It more efficacious scheme, corresponding median effective dose (ED50) ± standard error mean (SEM) values 49.8 ± 6.0 42.4 ± 0.2 mg/kg for antiedematous effects, respectively. Prophylactic treatments with matricaria caused effect dextran-induced lower efficacy than model. In p.o., slight histamine-induced edema. These results suggest that bisabolol-oxide-rich may be against pain present various inflammatory conditions, which supports traditional uses. Copyright © 2013 John Wiley & Sons, Ltd.