Canalicular multispecific organic anion transporter ABCC2
作者： Morimasa Wada , Takeshi Uchiumi , Michihiko Kuwano
DOI: 10.1007/978-1-4419-9023-5_18
关键词: Sulfonylurea receptor 、 Nucleotide 、 Multiple drug resistance 、 ABCC2 Gene 、 Molecular biology 、 ATP-binding cassette transporter 、 Cystic fibrosis transmembrane conductance regulator 、 Chemistry 、 Subfamily 、 Multidrug resistance-associated protein 2
摘要: The ABCC2 protein, also designated the canalicular multispecific organic anion transporter (cMOAT) or multidrug resistance protein 2 (MRP2), belongs to subfamily C of ABC proteins (http://nutrigene.4t. com/humanabc.htm). It is now known that this comprises 12 members (Figure 1), including six MRP-related (ABCCl-6, Cole et at. 1992; Paulusma 1996; Taniguchi Kool 1997; Suguki al. Lee 1998; 1999; McAleer Schuetz 1999), cystic fibrosis transmembrane conductance regulator (CFTR), and sulfonylurea receptors SUR1 SUR2. One major characteristics relatively low sequence homology between their NH2-and COOH-terminal nucleotide binding domains (NBDs).
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