The Catechol-Methyltransferase rs4680 G>A Polymorphism is Associated with Uterine Leiomyoma Susceptibility
作者： Mina Heydari , Saeid Ghorbian , Manizheh Sayyah Melli
DOI: 10.5812/GCT.86258
关键词: rs4680 、 Genotype frequency 、 Internal medicine 、 Restriction fragment length polymorphism 、 Endocrinology 、 Polymerase chain reaction 、 Uterine leiomyoma 、 Gene polymorphism 、 Medicine 、 Peripheral blood 、 Catechol Methyltransferase
摘要: Background: Uterine leiomyoma (ULM) is one of the most common medical conditions where molecular pathogenesis in women still unknown. Objectives: The aim present investigation was to demonstrate association between catechol-methyltransferase (COMT) (rs4680 G>A) gene polymorphism with risk ULM. Methods: In case-control study we included 200 peripheral blood samples women, which consisted 100 ULM and who were healthy. genotype frequencies assessed using polymerase chain reaction - restriction fragment length (PCR-RFLP) method. Results: COMT (rs4680) AA + GG vs. GA revealed a significant (OR = 2.453; CI 1.274 4.723, P 0.006). Conclusions: findings suggested that may be contributed as predisposing factor
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