Polymorphism of catechol-o-methyltransferase and uterine leiomyoma

摘要: Uterine leiomyoma (ULM) is the most common gynecological benign tumor that affecting around 20–50 % of women over age 30. Although its molecular pathogenesis still unknown, ULM has a multifactorial etiology determined by both genetics and environmental factors. The present study was designed to find out whether Val158Met polymorphism in catechol-o-methyltransferase (COMT) gene associated with risk ULM. We analyzed COMT 105 ULMs patients healthy subjects using polymerase chain reaction-based restriction fragment length assay. found remarkably similar frequencies compared controls for genotypes alleles, no association between this (p = 0.46). 158 Met allele large (≥5 cm) fibroids higher than small (<5 cm) fibroids, significant fibroid size (p = 0.011, OR 0.50, 95 %CI 0.28–0.90). Our results reflect not an increased ULMs, but may be factor development Turkish