The Reactivity of the Sulfhydryl Group in Glutathione and Related Peptides
作者： REINHOLD BENESCH , RUTH E. BENESCH , WILLIAM I. ROGERS
DOI: 10.1016/B978-1-4832-2900-3.50007-9
关键词: Reagent 、 Reactivity (chemistry) 、 Urea 、 Glutathione 、 Medicinal chemistry 、 Group (periodic table) 、 Hydrogen bond 、 Organic chemistry 、 Sh groups 、 Macromolecule 、 Chemistry
摘要: Publisher Summary The reactivity of the sulfhydryl group in different thiols varies enormously. changes —SH groups under influence certain denaturing agents, as observed proteins, are not confined to these macromolecules, but some small-molecular thiols, such glutathione, can also be altered by agents known cause protein denaturation. chemical reagents that have been used bring about denaturation urea and guanidinium salts. results with salts show even 7 M inhibited still fully reactive a further large increase nitroprusside color glutathione occurs presence 3 concentrations At pH values at which is yet ionized, hydrogen bonds could formed participation atom itself.
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