Implementation of alternative test strategies for the safety assessment of engineered nanomaterials

摘要: Nanotechnology introduces a new field that requires novel approaches and methods for hazard risk assessment. For an appropriate scientific platform safety assessment, nanoscale properties functions of engineered nanomaterials (ENMs), including how the physicochemical materials relate to mechanisms injury at nano–bio interface, must be considered. Moreover, this rapidly advancing test strategies allow multiple toxicants screened in robust, mechanism-based assays which bulk investigation can carried out cellular biomolecular level whilst maintaining limited animal use is based on contribution toxicological pathways pathophysiology disease. First, predictive approach assessment ENMs will discussed against background ‘21st-century vision’ using alternative (ATSs) perform large numbers untested chemicals, thereby reducing backlog could otherwise become problem nanotechnology. An ATS defined here as experiments or refinement/reduction traditional testing. Secondly, selecting toxicity screen pulmonary potential carbon nanotubes metal oxides discussed, well these high-content high-throughput testing data used ranking, regulatory decision-making ‘safer-by-design’ strategies. Finally, utility disadvantages ENM it assist 21st-century vision, addressed.