Targeting the Akt/mTOR pathway in Brca1-deficient cancers.
作者： T Xiang , Y Jia , D Sherris , S Li , H Wang
DOI: 10.1038/ONC.2010.603
关键词: mTORC2 、 Cancer research 、 Protein kinase B 、 PI3K/AKT/mTOR pathway 、 Phosphorylation 、 Carcinogenesis 、 AKT1 、 Tumor suppressor gene 、 Biology 、 RPTOR
摘要: … of Brca1 expression or mutations of the Brca1 gene activate … from 101 breast cancer patients who underwent mastectomy or … mutations and the expression of pAkt and Brca1. In all, 44 …
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sci-hub.se 参考文章(42)
Alfonso Bellacosa, C. Chandra Kumar, Antonio Di Cristofano, Joseph Robert Testa, Activation of AKT kinases in cancer: implications for therapeutic targeting. Advances in Cancer Research. ,vol. 94, pp. 29- 86 ,(2005) , 10.1016/S0065-230X(05)94002-5
Cindy A. Wilson, Lillian Ramos, Maria R. Villaseñor, Karl H. Anders, Michael F. Press, Kathy Clarke, Beth Karlan, Jun-Jie Chen, Ralph Scully, David Livingston, Robert H. Zuch, Michael H. Kanter, Sylvan Cohen, Frank J. Calzone, Dennis J. Slamon, Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas Nature Genetics. ,vol. 21, pp. 236- 240 ,(1999) , 10.1038/6029
Xiaoling Xu, Wenhui Qiao, Steven P. Linke, Liu Cao, Wen-Mei Li, Priscilla A. Furth, Curtis C. Harris, Chu-Xia Deng, Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis Nature Genetics. ,vol. 28, pp. 266- 271 ,(2001) , 10.1038/90108
Shian-ling Ding, Lai-Fa Sheu, Jyh-Cherng Yu, Tseng-Long Yang, BeFong Chen, Fur-jiang Leu, Chen-Yang Shen, Expression of Estrogen Receptor-α and Ki67 in Relation to Pathological and Molecular Features in Early-Onset Infiltrating Ductal Carcinoma Journal of Biomedical Science. ,vol. 11, pp. 911- 919 ,(2004) , 10.1007/BF02254376
Mohammed A. Aleskandarany, Emad A. Rakha, Mohamed A. Ahmed, Desmond G. Powe, Ian O. Ellis, Andrew R. Green, Clinicopathologic and molecular significance of phospho-Akt expression in early invasive breast cancer. Breast Cancer Research and Treatment. ,vol. 127, pp. 407- 416 ,(2011) , 10.1007/S10549-010-1012-Y
Kada Peela Bheeman Dinesh, Halagowder Devaraj, Vadivel Murugan, Ramamurthy Rajaraman, Sivasidhambaram Niranjali, Analysis of Loss of heterozygosity and immunohistochemistry in BRCA1 gene in sporadic breast cancers Molecular and Cellular Biochemistry. ,vol. 287, pp. 177- 183 ,(2006) , 10.1007/S11010-005-9097-Z
Julie A Wickenden, Christine J Watson, Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts. Breast Cancer Research. ,vol. 12, pp. 202- 202 ,(2010) , 10.1186/BCR2558
Alejo Efeyan, David M Sabatini, mTOR and cancer: many loops in one pathway Current Opinion in Cell Biology. ,vol. 22, pp. 169- 176 ,(2010) , 10.1016/J.CEB.2009.10.007
Steven G Brodie, Chu-Xia Deng, BRCA1-associated tumorigenesis: what have we learned from knockout mice? Trends in Genetics. ,vol. 17, pp. S18- S22 ,(2001) , 10.1016/S0168-9525(01)02451-9
Tove Kirkegaard, Caroline J Witton, Liane M McGlynn, Sian M Tovey, Barbara Dunne, Alison Lyon, John MS Bartlett, AKT activation predicts outcome in breast cancer patients treated with tamoxifen. The Journal of Pathology. ,vol. 207, pp. 139- 146 ,(2005) , 10.1002/PATH.1829