Activation of AKT kinases in cancer: implications for therapeutic targeting.

作者: Alfonso Bellacosa , C. Chandra Kumar , Antonio Di Cristofano , Joseph Robert Testa

DOI: 10.1016/S0065-230X(05)94002-5

关键词: AKT3Cell biologySignal transductionBiologyCancerAKT2PI3K/AKT/mTOR pathwayProtein kinase BAKT1Kinase

摘要: … many types of cancer, indicating that AKT activation is one of … AKT kinases, examples of therapeutic modulation of the AKT … target molecular components of the AKT pathway for cancer …

参考文章(248)
Mary-Ann Bjornsti, Peter J Houghton, Lost in translation Cancer Cell. ,vol. 5, pp. 519- 523 ,(2004) , 10.1016/J.CCR.2004.05.027
D. H. Kim, D. M. Sabatini, Raptor and mTOR: Subunits of a nutrient-sensitive complex Current Topics in Microbiology and Immunology. ,vol. 279, pp. 259- 270 ,(2004) , 10.1007/978-3-642-18930-2_15
Bellacosa A, Tsichlis Pn, Gonzalez-Portal Me, Datta K, Franke Tf, Taguchi T, Ahmed Nn, Testa, The proteins encoded by c-akt and v-akt differ in post-translational modification, subcellular localization and oncogenic potential. Oncogene. ,vol. 8, pp. 1957- 1963 ,(1993)
X. Long, F. Müller, J. Avruch, TOR action in mammalian cells and in Caenorhabditis elegans. Current Topics in Microbiology and Immunology. ,vol. 279, pp. 115- 138 ,(2004) , 10.1007/978-3-642-18930-2_8
Floyd H. Thompson, Mark A. Nelson, Jeffrey M. Trent, Xin-Yuan Guan, Yun Liu, Jin-Ming Yang, Julia Emerson, Laurence Adair, Julie Wymer, Celia Balfour, Kathy Massey, Ronald Weinstein, David S. Alberts, Raymond Taetle, Amplification of 19q13.1–q13.2 sequences in ovarian cancer: G-band, FISH, and molecular studies Cancer Genetics and Cytogenetics. ,vol. 87, pp. 55- 62 ,(1996) , 10.1016/0165-4608(95)00248-0
A.D. Reith, C. Ellis, S.D. Lyman, D.M. Anderson, D.E. Williams, A. Bernstein, T. Pawson, Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. The EMBO Journal. ,vol. 10, pp. 2451- 2459 ,(1991) , 10.1002/J.1460-2075.1991.TB07784.X
C. G. Proud, Role of mTOR signalling in the control of translation initiation and elongation by nutrients. Current Topics in Microbiology and Immunology. ,vol. 279, pp. 215- 244 ,(2004) , 10.1007/978-3-642-18930-2_13
Aye Aye Thant, Akihiro Nawa, Fumitaka Kikkawa, Yasukatu Ichigotani, Yangying Zhang, Thet Thet Sein, A.R.M. Ruhul Amin, Michinari Hamaguchi, Fibronectin activates matrix metalloproteinase-9 secretion via the MEK1-MAPK and the PI3K-Akt pathways in ovarian cancer cells. Clinical & Experimental Metastasis. ,vol. 18, pp. 423- 428 ,(2000) , 10.1023/A:1010921730952
Satoshi Tanno, Sachie Tanno, Y Mitsuuchi, Deborah A Altomare, G H Xiao, Joseph R Testa, AKT Activation Up-Regulates Insulin-like Growth Factor I Receptor Expression and Promotes Invasiveness of Human Pancreatic Cancer Cells Cancer Research. ,vol. 61, pp. 589- 593 ,(2001)