AKT Activation Up-Regulates Insulin-like Growth Factor I Receptor Expression and Promotes Invasiveness of Human Pancreatic Cancer Cells
作者： Satoshi Tanno , Sachie Tanno , Y Mitsuuchi , Deborah A Altomare , G H Xiao
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摘要: Insulin-like growth factor I receptor (IGF-IR) is frequently overexpressed in several types of human malignancy and associated with invasion metastasis tumor cells. Recently, IGF-IR expression was reported to be up-regulated the pancreatic cancer cell line PANC-1 when cells were stably transfected active Src. The downstream targets Src that lead up-regulation previously unknown. We demonstrate here AKT regulates AsPC-1 Cells exhibited significantly more protein compared vector-transfected Overexpression wild-type or constitutively (i.e., AKT1 AKT2) also resulted elevated expression. levels higher than In vitro kinase assays showed kinases are activated by inhibited dominant negative suppressor PTEN. Furthermore, AKT-induced down-regulated dominant-negative addition, presence IGF-I shown have enhanced invasiveness control These data provide evidence for a link between signaling regulation promotes through
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