Raptor and mTOR: Subunits of a nutrient-sensitive complex
作者： D. H. Kim , D. M. Sabatini
DOI: 10.1007/978-3-642-18930-2_15
关键词:
摘要: mTOR/RAFT1/FRAP is the target of FKBP12-rapamycin complex as well a central component nutrient- and hormone-sensitive pathway that controls cellular growth. Recent work reveals mTOR interacts with novel evolutionarily conserved protein we named raptor, for “regulatory associated mTOR.” Raptor has several roles in pathway. It necessary nutrient-mediated activation downstream effector S6K1 increases cell size. In addition, under conditions repress pathway, association raptor strengthened, leading to decrease kinase activity. critical regulates growth response nutrient levels by associating mTOR.
springer.com
sci-hub.st 参考文章(40)
John C. Lawrence, Gregory J. Brunn, Insulin signaling and the control of PHAS-I phosphorylation. Progress in molecular and subcellular biology. ,vol. 26, pp. 1- 31 ,(2001) , 10.1007/978-3-642-56688-2_1
David Cortez, Saritha Guntuku, Jun Qin, Stephen J Elledge, ATR and ATRIP: Partners in Checkpoint Signaling Science. ,vol. 294, pp. 1713- 1716 ,(2001) , 10.1126/SCIENCE.1065521
Hugo Stocker, Ernst Hafen, Genetic control of cell size. Current Opinion in Genetics & Development. ,vol. 10, pp. 529- 535 ,(2000) , 10.1016/S0959-437X(00)00123-4
Eva J. Neer, Carl J. Schmidt, Raman Nambudripad, Temple F. Smith, The ancient regulatory-protein family of WD-repeat proteins Nature. ,vol. 371, pp. 297- 300 ,(1994) , 10.1038/371297A0
Jacques Montagne, Mary J Stewart, Hugo Stocker, Ernst Hafen, Sara C Kozma, George Thomas, Drosophila S6 Kinase: A Regulator of Cell Size Science. ,vol. 285, pp. 2126- 2129 ,(1999) , 10.1126/SCIENCE.285.5436.2126
Kenta Hara, Kazuyoshi Yonezawa, Mark T. Kozlowski, Tadanori Sugimoto, Khurshid Andrabi, Qing-Ping Weng, Masato Kasuga, Ikuo Nishimoto, Joseph Avruch, Regulation of eIF-4E BP1 Phosphorylation by mTOR Journal of Biological Chemistry. ,vol. 272, pp. 26457- 26463 ,(1997) , 10.1074/JBC.272.42.26457
Yimin Fang, Montserrat Vilella-Bach, Rebecca Bachmann, Asa Flanigan, Jie Chen, Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling Science. ,vol. 294, pp. 1942- 1945 ,(2001) , 10.1126/SCIENCE.1066015
Tobias Schmelzle, Michael N Hall, TOR, a Central Controller of Cell Growth Cell. ,vol. 103, pp. 253- 262 ,(2000) , 10.1016/S0092-8674(00)00117-3
P. H. Scott, G. J. Brunn, A. D. Kohn, R. A. Roth, J. C. Lawrence, Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 7772- 7777 ,(1998) , 10.1073/PNAS.95.13.7772
David M Sabatini, Roxanne K Barrow, Seth Blackshaw, Patrick E Burnett, Michael M Lai, Michael E Field, Ben A Bahr, Joachim Kirsch, Heinrich Betz, Solomon H Snyder, Interaction of RAFT1 with Gephyrin Required for Rapamycin-Sensitive Signaling Science. ,vol. 284, pp. 1161- 1164 ,(1999) , 10.1126/SCIENCE.284.5417.1161