Interaction of RAFT1 with Gephyrin Required for Rapamycin-Sensitive Signaling
作者： David M Sabatini , Roxanne K Barrow , Seth Blackshaw , Patrick E Burnett , Michael M Lai
DOI: 10.1126/SCIENCE.284.5417.1161
关键词:
摘要: RAFT1 (rapamycin and FKBP12 target 1; also called FRAP or mTOR) is a member of the ATM (ataxia telangiectasia mutated)-related family proteins functions as in vivo mediator effects immunosuppressant rapamycin an important regulator messenger RNA translation. In mammalian cells interacted with gephyrin, widely expressed protein necessary for clustering glycine receptors at cell membrane neurons. mutants that could not associate gephyrin failed to signal downstream molecules, including p70 ribosomal S6 kinase eIF-4E binding protein, 4E-BP1. The interaction ascribes function large amino-terminal region ATM-related reveals role transduction gephyrin.
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