Naturally Occurring Antibodies/Autoantibodies in Polyclonal Immunoglobulin Concentrates

摘要: It was a long way from the use of hyperimmune animal sera for treatment toxin-producing infections to production polyclonal, polyspecific human immunoglobulin preparations and NAbs as therapeutic tools autoimmune inflammatory diseases. Some highlights development knowledge in blood fractionation techniques, basic science clinical wisdom are reviewed this chapter. Proudly we mention outstanding contribution Swiss scientists clinicians IVIG tool some otherwise untreatable diseases or taking advantage its low adverse event profile long-term other chronic This chapter summarizes characteristics effects humans which present IgG concentrates. We call attention fact that data remain, at least part, incomplete, among others because even with most efficient large-scale techniques available not more than approximately 50% total plasma can be fractionated into an G concentrate.