A preparation of modified immune serum globulin (human) suitable for intravenous administration

摘要: Numerous methods have been used in previous attempts to prepare a human gamma globulin solution suitable for intravenous administration. These include fractionation schemes, enzyme digestion, manipulations of pH, and various combinations these methods. The selective reduction alkylation process that we developed Gamimune causes controlled reproducible modification limited number disulfide bonds the hinge region IgG, resulting functional antibody molecule undiminished molecular weight possessing complement-binding properties Subtle changes structure or may be caused by trace hydrolysis extremes pH temperature are avoided. biochemical characterization immune (Gamimune) is described herein, attributes this chemically modified IgG compared with some other preparations.