Stereoelectroencephalography-guided radiofrequency thermocoagulation for hypothalamic hamartoma: Electroclinical patterns and the relationship with surgical prognosis.

摘要: Abstract Background Radiofrequency thermocoagulation (RFTC) guided by stereo-electroencephalography (SEEG) has been proved to be a safe method reduce seizure frequency in patients with drug-resistant epilepsy. However, there are few reports addressing the value and safety of this procedure hypothalamic hamartoma (HH). Objective To present results our experience using SEEG-guided RFTC HH epilepsy, identify outcome predictors. Methods We retrospectively reviewed clinical surgical characteristics 27 HH-related epilepsy center between 2015 2019. All underwent invasive recordings SEEG before was performed. reported predictors postoperative follow-up concerning efficacy (mean follow-up, 27.3 months; range, 12–63). Surgical strategy also analyzed. Results Nineteen (70.4%) achieved Engel’s class I outcome, while 4 (14.8%) did not show significant improvement. Of all observed seizures, two different onset patterns intracranial electrophysiology recorded were observed. Patients presented focal low-voltage fast activity more likely obtain freedom (p = 0.045), classification (p = 0.478), volume (p = 0.546), history resection (p = 0.713), types (p = 0.859), or duration (p = 0.415) showed no effect on outcome. Weight gain most common long-term complication (18.5%). Conclusion The can guide ablation serve as an important factor predict favorable outcomes. offer minimally low-risk approach excellent Disconnecting attachment should appropriate best