Perspectives of induced pluripotent stem cells for cardiovascular system regeneration
作者： Mária Csöbönyeiová , Štefan Polák , L’uboš Danišovič
关键词: SOX2 、 KLF4 、 Regenerative medicine 、 Regeneration (biology) 、 Personalized medicine 、 Disease 、 Induced pluripotent stem cell 、 Medicine 、 Embryonic stem cell 、 Neuroscience
摘要: Induced pluripotent stem cells (iPSCs) hold great promise for basic research and regenerative medicine. They offer the same advantages as embryonic (ESCs) moreover new perspectives personalized iPSCs can be generated from adult somatic tissues by over-expression of a few defined transcription factors, including Oct4, Sox2, Klf4, c-myc. For medicine in particular, technology provides hope patients with incurable diseases or potentially fatal disorders such heart failure. The endogenous potentials hearts are extremely limited insufficient to compensate myocardial loss occurring after infarction. Recent discoveries have demonstrated that potential significantly advance future cardiovascular therapies. Moreover, genetic basis their disease. This human iPSC derivates tremendous disease models. paper reviews current applications discusses progress modeling using iPSCs-derived cardiac cells.
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