Induced Pluripotent Stem Cells in Cardiovascular Research

摘要: The discovery that somatic cells can be reprogrammed to induced pluripotent stem (iPSC) by overexpression of a combination transcription factors bears the potential spawn wealth new applications in both preclinical and clinical cardiovascular research. Disease modeling, which is accomplished deriving iPSC lines from patients affected heritable diseases then studying pathophysiology differentiated these patient-specific lines, so far most advanced applications. Long-QT syndrome catecholaminergic polymorphic ventricular tachycardia are two heart rhythm disorders have been already successfully modeled several groups using this approach, will likely serve model other mono- or polygenetic future. Test systems based on derived might prove beneficial screen for novel drugs unwanted drug side effects individualize medical therapy. application cell therapy disorders, albeit promising, only become feasible if problem biological safety mastered.