The Neuroimmunology of Cancer

摘要: Decreased immune surveillance is thought to be one of the mechanisms by which neoplastic cells are able thrive. When cancer located in nervous system, an privileged site, its ability evade detection, and targeting may contribute aggressive behavior. Furthermore, high-grade gliomas, most frequent lethal primary brain tumors, induce both a local systemic state suppression that hampers efforts manipulate system as effective therapeutic modality. On other hand, there rare instances when response elucidated against causes injury without direct spread tumor. Although neural mediated autoimmune process, cases it uncertain if caused humoral response, cellular or combination both. This chapter reviews concepts related unique relationship between systems, present, well modalities employed structures affected directly tumor indirectly case paraneoplastic neurologic syndromes. The distinct immunologic characteristics central (CNS) become more complex setting disease. In 2008, approximately 1,437,180 new cases, including 21,810 arising from were diagnosed USA [1]. Gliomas, type characterized infiltration normal cerebral tissue, but this rarely results metastases. microenvironment shows meager inflammatory often accompanied suppression. These alterations might considered epiphenomena unrelated pathogenesis, experimental clinical observations suggest plays important role glioma biology. Our current concept immunobiology lends strong support idea manipulating approach for tumors. Glioma immunotherapy has evolved over years, unfortunately yet, major success. Nevertheless, extraneural neoplasms can trigger have repercussions system. interactions cause syndromes aptly termed some antibodies been identified element responsible phenomenon, tumors spinal cord, pathogenesis these not clearly elucidated.