The fate of competing beneficial mutations in an asexual population
作者： Philip J. Gerrish , Richard E. Lenski
DOI: 10.1007/978-94-011-5210-5_12
关键词: Population 、 Biology 、 Mutation rate 、 Clonal interference 、 Human genetics 、 Genetics 、 Fixation (population genetics)
摘要: In sexual populations, beneficial mutations that occur in different lineages may be recombined into a single lineage. asexual however, clones carry such alternative compete with one another and, thereby, interfere the expected progression of given mutation to fixation. From theoretical exploration ‘clonal interference’, we have derived (1) fixation probability for mutations, (2) an substitution rate, (3) coefficient selection realized substitutions, (4) rate fitness increase, (5) transiently achieves polymorphic frequency (≥ 1%), and (6) majority status. Based on (3), were able estimate distribution mutational effects from changes mean evolving E. coli population.
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