Gas chromatographic–mass spectrometric analysis of erythrocyte 3-deoxyglucosone in hemodialysis patients

作者: Saori Tsukushi , Kaoru Shimokata , Toshimitsu Niwa

DOI: 10.1016/S0378-4347(99)00150-4

关键词: Gas chromatographyHemodialysisUltrafiltration (renal)Chemistry3-DeoxyglucosoneGas chromatography–mass spectrometryRed blood cellMass spectrometrySelected ion monitoringChromatography

摘要: The erythrocyte levels of 3-deoxyglucosone (3-DG) were measured by a selected ion monitoring method gas chromatography-chemical ionization mass spectrometry using [13C6]-3-DG as an internal standard. Because the 3-DG after deproteinization ethanol 18 times higher than those ultrafiltration, we used for measurement total in erythrocytes. concentration was significantly elevated hemodialysis (HD) patients compared with healthy subjects. Although HD treatment could remove efficiently, its post-HD still

参考文章(31)
Bucala R, Vlassara H, Striker L, Pathogenic Effects of Advanced Glycosylation: Biochemical, Biologic, and Clinical Implications for Diabetes and Aging Laboratory Investigation. ,vol. 70, pp. 138- 151 ,(1994)
M Oimomi, M Kasuga, N Igaki, M Sakai, S Miyata, T Ohara, Y Miyauchi, H Shoda, H Yamada, H Yatabe, Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction. Journal of Biological Chemistry. ,vol. 269, pp. 20275- 20280 ,(1994) , 10.1016/S0021-9258(17)31987-7
A Petersen, F Kappler, B S Szwergold, T R Brown, Fructose metabolism in the human erythrocyte. Phosphorylation to fructose 3-phosphate Biochemical Journal. ,vol. 284, pp. 363- 366 ,(1992) , 10.1042/BJ2840363
A Petersen, B S Szwergold, F Kappler, M Weingarten, T R Brown, Identification of sorbitol 3-phosphate and fructose 3-phosphate in normal and diabetic human erythrocytes. Journal of Biological Chemistry. ,vol. 265, pp. 17424- 17427 ,(1990) , 10.1016/S0021-9258(18)38178-X
F Hayase, R H Nagaraj, S Miyata, F G Njoroge, V M Monnier, Aging of proteins: immunological detection of a glucose-derived pyrrole formed during maillard reaction in vivo. Journal of Biological Chemistry. ,vol. 264, pp. 3758- 3764 ,(1989) , 10.1016/S0021-9258(19)84914-1
Hitoo Iwase, Ikuko Ishii-Karakasa, Yoshitada Yajima, Kyoko Hotta, Ei Fujii, Quantitation of the glycation intermediate 3-deoxyglucosone by oxidation with rabbit liver oxoaldehyde dehydrogenase to 2-keto-3-deoxygluconic acid followed by high-performance liquid chromatography Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 660, pp. 265- 270 ,(1994) , 10.1016/0378-4347(94)00313-0
E. Fujii, H. Iwase, I. Ishiikarakasa, Y. Yajima, K. Hotta, The Presence of 2-Keto-3-Deoxygluconic Acid and Oxoaldehyde Dehydrogenase Activity in Human Erythrocytes Biochemical and Biophysical Research Communications. ,vol. 210, pp. 852- 857 ,(1995) , 10.1006/BBRC.1995.1736
Toshimitsu Niwa, Mitsuhiko Sato, Tomoyuki Katsuzaki, Toshiyuki Tomoo, Takashi Miyazaki, Noriyuki Tatemichi, Yoshifumi Takei, Tadao Kondo, Amyloid β2-microglobulin is modified with Nε-(carboxymethyl)lysine in dialysis-related amyloidosis Kidney International. ,vol. 50, pp. 1303- 1309 ,(1996) , 10.1038/KI.1996.442
Y. Hamada, J. Nakamura, H. Fujisawa, H. Yago, E. Nakashima, N. Koh, N. Hotta, Effects of glycemic control on plasma 3-deoxyglucosone levels in NIDDM patients. Diabetes Care. ,vol. 20, pp. 1466- 1469 ,(1997) , 10.2337/DIACARE.20.9.1466