Effects of glycemic control on plasma 3-deoxyglucosone levels in NIDDM patients.

摘要: OBJECTIVE To clarify the effects of glycemic control on level 3-deoxyglucosone (3-DG), a reactive dicarbonyl compound, in plasma from diabetic patients. RESEARCH DESIGN AND METHODS Fasting samples were collected 15 healthy volunteers and 27 patients with NIDDM. Samples six poorly controlled before after improved for at least 2 months. Plasma 3-DG was determined by high-performance liquid chromatography (HPLC) as 2,3-diaminonaphthalene derivative. We observed relationship levels glucose or HbA 1c examined changes RESULTS significantly more increased than nondiabetic subjects (31.8 ± 11.3 vs. 12.8 5.2 ng/ml, means SD, P r = 0.56, ( 0.74, CONCLUSIONS The results indicate that is predominant determinant good would be important to reduce this metabolite.