Determination of protein charge variants with (imaged) capillary isoelectric focusing and capillary zone electrophoresis.
作者： Julia Kahle , Hermann Wätzig
关键词: Capillary electrophoresis 、 Capillary action 、 Isoelectric point 、 Sample preparation 、 Characterization (materials science) 、 Carrier Ampholytes 、 Biological system 、 Materials science 、 Isoelectric focusing 、 Charge (physics)
摘要: … in process development and quality control. Wang et al. 54 investigated mAb charge variants … of 23 FDA and EMA-approved therapeutic monoclonal antibodies as well as dalotuzumab …
sci-hub.se 参考文章(113)
Dávid Suba, Zoltán Urbányi, András Salgó, Capillary isoelectric focusing method development and validation for investigation of recombinant therapeutic monoclonal antibody. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 114, pp. 53- 61 ,(2015) , 10.1016/J.JPBA.2015.04.037
Manuel T. Velasquez, Ali Ramezani, Dominic S. Raj, Urea and protein carbamylation in ESRD: surrogate markers or partners in crime? Kidney International. ,vol. 87, pp. 1092- 1094 ,(2015) , 10.1038/KI.2015.78
Leslie A. Khawli, Sirj Goswami, Ryan Hutchinson, Zephania W. Kwong, Jihong Yang, Xiangdan Wang, Zhenling Yao, Alavattam Sreedhara, Tony Cano, Devin B. Tesar, Ihsan Nijem, David E. Allison, Pin Yee Wong, Yung-Hsiang Kao, Cynthia Quan, Amita Joshi, Reed J. Harris, Paul Motchnik, Charge variants in IgG1 mAbs. ,vol. 2, pp. 613- 624 ,(2010) , 10.4161/MABS.2.6.13333
Yan He, Jim Mo, Xiaoping He, Margaret Ruesch, Rapid Analysis of Charge Heterogeneity of Monoclonal Antibodies by Capillary Zone Electrophoresis and Imaged Capillary Isoelectric Focusing John Wiley & Sons, Ltd. pp. 293- 308 ,(2013) , 10.1002/9781118530009.CH16
Theresa Kristl, Hanno Stutz, Comparison of different mobilization strategies for capillary isoelectric focusing of ovalbumin variants. Journal of Separation Science. ,vol. 38, pp. 148- 156 ,(2015) , 10.1002/JSSC.201400890
Oscar Salas-Solano, Babu Kennel, SungAe Suhr Park, Kelly Roby, Zoran Sosic, Boris Boumajny, Sarah Free, Angelia Reed-Bogan, David Michels, Will McElroy, Pauline Bonasia, Mingfang Hong, Xiaoping He, Margaret Ruesch, Frank Moffatt, Steffen Kiessig, Brian Nunnally, Robustness of iCIEF methodology for the analysis of monoclonal antibodies: an interlaboratory study. Journal of Separation Science. ,vol. 35, pp. 3124- 3129 ,(2012) , 10.1002/JSSC.201200633
Melissa Hamm, Feng Wang, Richard R. Rustandi, Development of a capillary zone electrophoresis method for dose determination in a tetravalent dengue vaccine candidate Electrophoresis. ,vol. 36, pp. 2687- 2694 ,(2015) , 10.1002/ELPS.201500186
Junzi Cao, Wen Sun, Feifei Gong, Wanhui Liu, Charge profiling and stability testing of biosimilar by capillary isoelectric focusing. Electrophoresis. ,vol. 35, pp. 1461- 1468 ,(2014) , 10.1002/ELPS.201300471
Tobias Rakow, Sami El Deeb, Thomas Hahne, Deia Abd El-Hady, Hassan M. AlBishri, Hermann Wätzig, Investigating effects of sample pretreatment on protein stability using size‐exclusion chromatography and high‐resolution continuum source atomic absorption spectrometry Journal of Separation Science. ,vol. 37, pp. 2583- 2590 ,(2014) , 10.1002/JSSC.201400189
Xiaoping Z. He, Amy H. Que, Jim J. Mo, Analysis of charge heterogeneities in mAbs using imaged CE Electrophoresis. ,vol. 30, pp. 714- 722 ,(2009) , 10.1002/ELPS.200800636