Summary From the First Kidney Cancer Research Summit, September 12-13, 2019: A Focus on Translational Research.

作者: Toni K Choueiri , Michael B Atkins , Ziad Bakouny , Maria I Carlo , Charles G Drake

DOI: 10.1093/JNCI/DJAA064

关键词: Intensive care medicineTranslational researchKidney cancerSummitPredictive biomarkerRenal cell carcinomaImmune checkpointSingle cell sequencingTumor microenvironmentMedicine

摘要: Kidney cancer is one of the 10 most common cancers both in United States and worldwide. Until this year, there had not previously been a conference focused on translational studies broad heterogeneous group kidney cancers. Therefore, researchers, clinicians, patient advocates dedicated to renal cell carcinoma launched Cancer Research Summit (KCRS) spur collaboration further therapeutic advances these tumors. This commentary aims summarize oral presentations serve as record for future iterations meeting. The KCRS sessions addressed tumor microenvironment, novel methods drug delivery, single sequencing strategies, immune checkpoint blockade cellular therapies, predictive biomarkers, rare variants In addition, meeting included 2 promote scientific mentoring research collaborations. A subsequent will be planned fall 2020.

参考文章(62)
Caleb F Davis, Christopher J Ricketts, Min Wang, Lixing Yang, Andrew D Cherniack, Hui Shen, Christian Buhay, Hyojin Kang, Sang Cheol Kim, Catherine C Fahey, Kathryn E Hacker, Gyan Bhanot, Dmitry A Gordenin, Andy Chu, Preethi H Gunaratne, Michael Biehl, Sahil Seth, Benny A Kaipparettu, Christopher A Bristow, Lawrence A Donehower, Eric M Wallen, Angela B Smith, Satish K Tickoo, Pheroze Tamboli, Victor Reuter, Laura S Schmidt, James J Hsieh, Toni K Choueiri, A Ari Hakimi, Chad J Creighton, Margaret Morgan, David A Wheeler, Richard A Gibbs, Sabina Signoretti, A Gordon Robertson, Elizabeth P Henske, David J Kwiatkowski, Christopher Ricketts, W Marston Linehan, Michael Seiler, W Kimryn Rathmell, Peter W Laird, Brian Shuch, Donna Muzny, Hsu Chao, Mike Dahdouli, Liu Xi, Nipun Kakkar, Jeffrey G Reid, Brittany Downs, Jennifer Drummond, Donna Morton, Harsha Doddapaneni, Lora Lewis, Adam English, Qingchang Meng, Christie Kovar, Qiaoyan Wang, Walker Hale, Alicia Hawes, Divya Kalra, Kimberly Walker, Bradley A Murray, Carrie Sougnez, Gordon Saksena, Scott L Carter, Steven E Schumacher, Barbara Tabak, Travis I Zack, Gad Getz, Rameen Beroukhim, Stacey B Gabriel, Matthew Meyerson, Adrian Ally, Miruna Balasundaram, Inanc Birol, Denise Brooks, Yaron SN Butterfield, Eric Chuah, Amanda Clarke, Noreen Dhalla, Ranabir Guin, Robert A Holt, Katayoon Kasaian, Darlene Lee, Haiyan I Li, Emilia Lim, Yussanne Ma, Michael Mayo, Richard A Moore, Andrew J Mungall, Jacqueline E Schein, Payal Sipahimalani, Angela Tam, Nina Thiessen, Tina Wong, Steven JM Jones, Marco A Marra, J Todd Auman, Donghui Tan, Shaowu Meng, Corbin D Jones, Katherine A Hoadley, Piotr A Mieczkowski, Lisle E Mose, Stuart R Jefferys, Jeffrey Roach, Umadevi Veluvolu, Matthew D Wilkerson, Scot Waring, Elizabeth Buda, Junyuan Wu, Tom Bodenheimer, Alan P Hoyle, Janae V Simons, Mathew G Soloway, Saianand Balu, Joel S Parker, D Neil Hayes, Charles M Perou, Daniel J Weisenberger, Moiz S Bootwalla, Timothy Triche, Phillip H Lai, David J Van Den Berg, Stephen B Baylin, Fengju Chen, Cristian Coarfa, Michael S Noble, Daniel DiCara, Hailei Zhang, Juok Cho, David I Heiman, Nils Gehlenborg, Doug Voet, Pei Lin, Scott Frazer, Petar Stojanov, Yingchun Liu, Lihua Zou, Jaegil Kim, Michael S Lawrence, Lynda Chin, Alexei Protopopov, Xingzhi Song, Jianhua Zhang, Angeliki Pantazi, Angela Hadjipanayis, Eunjung Lee, Lovelace J Luquette, None, The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma Cancer Cell. ,vol. 26, pp. 319- 330 ,(2014) , 10.1016/J.CCR.2014.07.014
Lucia B. Jilaveanu, Joshua Sznol, Saadia A. Aziz, Dylan Duchen, Harriet M. Kluger, Robert L. Camp, CD70 expression patterns in renal cell carcinoma. Human Pathology. ,vol. 43, pp. 1394- 1399 ,(2012) , 10.1016/J.HUMPATH.2011.10.014
R. Komerofsky, D. Middleton, H. Rood, L. Menchaca, New allele frequency database: www.allelefrequencies.net Tissue Antigens. ,vol. 61, pp. 403- 407 ,(2003)
E Cherkasova, E Malinzak, S Rao, Y Takahashi, V N Senchenko, A V Kudryavtseva, M L Nickerson, M Merino, J A Hong, D S Schrump, R Srinivasan, W M Linehan, X Tian, M I Lerman, R W Childs, Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer. Oncogene. ,vol. 30, pp. 4697- 4706 ,(2011) , 10.1038/ONC.2011.179
Yoshiyuki Takahashi, Nanae Harashima, Sachiko Kajigaya, Hisayuki Yokoyama, Elena Cherkasova, J. Philip McCoy, Ken-ichi Hanada, Othon Mena, Roger Kurlander, Tawab Abdul, Ramaprasad Srinivasan, Andreas Lundqvist, Elizabeth Malinzak, Nancy Geller, Michael I. Lerman, Richard W. Childs, Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells Journal of Clinical Investigation. ,vol. 118, pp. 1099- 1109 ,(2008) , 10.1172/JCI34409
Nizar M. Tannir, Eric Jonasch, Laurence Albiges, Emre Altinmakas, Chaan S. Ng, Surena F. Matin, Xuemei Wang, Wei Qiao, Zita Dubauskas Lim, Pheroze Tamboli, Priya Rao, Kanishka Sircar, Jose A. Karam, David F. McDermott, Christopher G. Wood, Toni K. Choueiri, Everolimus Versus Sunitinib Prospective Evaluation in Metastatic Non–Clear Cell Renal Cell Carcinoma (ESPN): A Randomized Multicenter Phase 2 Trial European Urology. ,vol. 69, pp. 866- 874 ,(2016) , 10.1016/J.EURURO.2015.10.049
Richard Tavaré, Helena Escuin-Ordinas, Stephen Mok, Melissa N. McCracken, Kirstin A. Zettlitz, Felix B. Salazar, Owen N. Witte, Antoni Ribas, Anna M. Wu, An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy. Cancer Research. ,vol. 76, pp. 73- 82 ,(2016) , 10.1158/0008-5472.CAN-15-1707
Robert J Motzer, Bernard Escudier, David F McDermott, Saby George, Hans J Hammers, Sandhya Srinivas, Scott S Tykodi, Jeffrey A Sosman, Giuseppe Procopio, Elizabeth R Plimack, Daniel Castellano, Toni K Choueiri, Howard Gurney, Frede Donskov, Petri Bono, John Wagstaff, Thomas C Gauler, Takeshi Ueda, Yoshihiko Tomita, Fabio A Schutz, Christian Kollmannsberger, James Larkin, Alain Ravaud, Jason S Simon, Li-An Xu, Ian M Waxman, Padmanee Sharma, None, Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma The New England Journal of Medicine. ,vol. 373, pp. 1803- 1813 ,(2015) , 10.1056/NEJMOA1510665
Andrew J Armstrong, Susan Halabi, Tim Eisen, Samuel Broderick, Walter M Stadler, Robert J Jones, Jorge A Garcia, Ulka N Vaishampayan, Joel Picus, Robert E Hawkins, John D Hainsworth, Christian K Kollmannsberger, Theodore F Logan, Igor Puzanov, Lisa M Pickering, Christopher W Ryan, Andrew Protheroe, Christine M Lusk, Sadie Oberg, Daniel J George, Everolimus versus sunitinib for patients with metastatic non-clear cell renal cell carcinoma (ASPEN): a multicentre, open-label, randomised phase 2 trial Lancet Oncology. ,vol. 17, pp. 378- 388 ,(2016) , 10.1016/S1470-2045(15)00515-X
Ed Reznik, Martin L Miller, Yasin Şenbabaoğlu, Nadeem Riaz, Judy Sarungbam, Satish K Tickoo, Hikmat A Al-Ahmadie, William Lee, Venkatraman E Seshan, A Ari Hakimi, Chris Sander, Mitochondrial DNA copy number variation across human cancers eLife. ,vol. 5, ,(2016) , 10.7554/ELIFE.10769