An Elegan(t) Screen for Drug-Microbe Interactions.
作者： Alison Vrbanac , Justine W. Debelius , Lingjing Jiang , James T. Morton , Pieter Dorrestein
DOI: 10.1016/J.CHOM.2017.04.014
关键词: Drug metabolism 、 Biology 、 Pharmacology 、 Drug discovery 、 Drug 、 Microbial metabolism 、 Anticancer drug 、 Computational biology
摘要: Microbes affect drug responses, but mechanisms remain elusive. Two papers in Cell exploit C. elegans to infer anticancer mechanisms. Through high-throughput screens of drug-microbe-host interactions, Garcia-Gonzalez et al. (2017) and Scott determine that bacterial metabolism underpins fluoropyrimidine cytotoxicity, providing a paradigm for unraveling metabolism.
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