Thiazole derivatives and use thereof

作者: Vincent Pomel , Jérôme Dorbais , David Covini , Anna Quattropani , Thomas Rueckle

DOI:

关键词: Graft rejectionPharmacologyKidneyLungThiazoleTransplantationChemistryBiochemistryCancerPlatelet aggregation

摘要: The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis autoimmune disorders inflammatory diseases, cardiovascular neurodegenerative bacterial or viral infections, kidney platelet aggregation, cancer, transplantation, graft rejection lung injuries.

参考文章(63)
Ralph Mazitschek, Frank Stieber, Athanassios Giannis, Herbert Waldmann, Klaus Hellmuth, Novel compounds for inhibition of Tie-2 ,(2002)
Andreas Floersheimer, Joseph Schoepfer, Andrea Vaupel, Pascal Furet, Keiichi Masuya, Guido Bold, Vito Guagnano, Thiazole and pyrazole derivatives as flt-3 kinase inhibitors ,(2004)
Marco Lopez-Ilasaca, J. Silvio Gutkind, Reinhard Wetzker, Phosphoinositide 3-Kinase γ Is a Mediator of Gβγ-dependent Jun Kinase Activation Journal of Biological Chemistry. ,vol. 273, pp. 2505- 2508 ,(1998) , 10.1074/JBC.273.5.2505
Dilip Bhumralkar, Mitchell David Nambu, Allen J. Borchardt, Shao Song Chu, Steven Lee Bender, Yi Michelle Yang, Suzanne Pritchett Benedict, Peng Zhengwei, Larry Andrew Alegria, Robert Steven Kania, Anna Maria Tempczyk-Russell, Sepehr c, o TransTech Pharma Sarshar, Diaminothiazoles and their use for inhibiting protein kinases ,(2000)
Craig Gerard, Barrett J. Rollins, Chemokines and disease Nature Immunology. ,vol. 2, pp. 108- 115 ,(2001) , 10.1038/84209
Takashi Inaba, Shohei Sakata, Tomoyuki Ikemoto, Atsunori Kashiwagi, Hiroshi Maegawa, Azole compound and medicinal use thereof ,(2002)
Clive Mccarthy, Louise Kirman, Judy Hayler, Catherine Leblanc, Mrinalini Sachin Oza, Lewis Whitehead, Peter Finan, Graham Charles Bloomfield, Ian Bruce, Lena Shukla, Nicola Elaine Press, 5-phenylthiazole derivatives and use as pi3 kinase inhibitors ,(2003)
Dario R. Alessi, Margaret A. Lawlor, PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? Journal of Cell Science. ,vol. 114, pp. 2903- 2910 ,(2001) , 10.1242/JCS.114.16.2903
Peter Storm, John Peter AstraZeneca R D Alderley Bailey, Joakim Larsson, Edward Jolyon AstraZeneca R D Alderley Griffen, Grigorios Nikitidis, Thomas Geoffrey Colerick AstraZeneca Reims Bird, Jean-Claude AstraZeneca Reims Arnould, Malena Bengtsson, 5-heteroaryl thiazoles and their use as pi3k inhibitors ,(2005)
C. R. Rasmussen, F. J. Villani, Jr., L. E. Weaner, B. E. Reynolds, A. R. Hood, L. R. Hecker, S. O. Nortey, A. Hanslin, M. J. Costanzo, E. T. Powell, A. J. Molinari, Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas Synthesis. ,vol. 1988, pp. 456- 459 ,(1988) , 10.1055/S-1988-27605