Thiazole derivative as dhodh inhibitor and use thereof
作者： 李洪林 , 徐玉芳 , 崔坤强 , 曹贤文 , 许鸣豪
DOI:
关键词: Rheumatoid arthritis 、 Chemistry 、 Transplant rejection 、 Stereochemistry 、 Thiazole derivative 、 Pharmacology
摘要: The present invention relates to a thiazole derivative, as represented in formula I, DHODH inhibitor and use thereof. compound of the can be used for treating or preventing DHODH-mediated diseases, including, but not limited to, rheumatoid arthritis autoimmune diseases such anti-tumor, anti-organ transplant rejection, anti-psoriasis.
lens.org 参考文章(15)
Bogislav Von Schmeling, Marshall Kulka, William A Harrison, Method of controlling plant growth with carboxamidothiazoles ,(1966)
Gavin Wood, Christopher Meades, Peter Martin Fischer, Andrew Osnowski, Shudong Wang, N-(4-(4-methylthiazol-5-yl) pyrimidin-2-yl) -n-phenylamines as antiproliferative compounds ,(2002)
Jiann-Jyh Huang, Johnson Lau, Modulators of hec1 activity and methods therefor ,(2011)
Vincent Pomel, Jérôme Dorbais, David Covini, Anna Quattropani, Thomas Rueckle, Thiazole derivatives and use thereof ,(2006)
D. Suciu, Reduction of Some 5‐Acylthiazoles by sodium borohydride Journal Fur Praktische Chemie-chemiker-zeitung. ,vol. 314, pp. 961- 964 ,(1972) , 10.1002/PRAC.19723140536
Breland Smith, Hui-Hua Chang, Federico Medda, Vijay Gokhale, Justin Dietrich, Angela Davis, Emmanuelle J. Meuillet, Christopher Hulme, Synthesis and biological activity of 2-aminothiazoles as novel inhibitors of PGE2 production in cells. Bioorganic & Medicinal Chemistry Letters. ,vol. 22, pp. 3567- 3570 ,(2012) , 10.1016/J.BMCL.2012.03.013
Moises Romero-Ortega, Adriana Aviles, Raymundo Cruz, Aydee Fuentes, Rosa Maria Gomez, Andres Plata, Synthesis of 4‐Substituted 2‐Phenylaminothiazoles from Amidines. A Convenient Route to 4‐Trichloromethylthiazoles. ChemInform. ,vol. 32, ,(2001) , 10.1002/CHIN.200110123
Günter Pappenberger, Tanja Schulz-Gasch, Eric Kusznir, Francis Müller, Michael Hennig, Structure-Assisted Discovery of an Aminothiazole Derivative as a Lead Molecule for Inhibition of Bacterial Fatty-Acid Synthesis. Acta Crystallographica Section D-biological Crystallography. ,vol. 63, pp. 1208- 1216 ,(2007) , 10.1107/S0907444907049852
Hai-Bo Shi, Shi-Jie Zhang, Qiu-Fu Ge, Dian-Wu Guo, Chao-Ming Cai, Wei-Xiao Hu, Synthesis and anticancer evaluation of thiazolyl–chalcones Bioorganic & Medicinal Chemistry Letters. ,vol. 20, pp. 6555- 6559 ,(2010) , 10.1016/J.BMCL.2010.09.041
Nha Huu Vo, Qinglin Che, Yu Xie, Shoujun Chen, Thiazole and thiadiazole compounds for inflammation and immune-related uses ,(2007)