Elevating SOX2 in prostate tumor cells upregulates expression of neuroendocrine genes, but does not reduce the inhibitory effects of enzalutamide
作者： Ethan P. Metz , Phillip J. Wilder , Jixin Dong , Kaustubh Datta , Angie Rizzino
DOI: 10.1002/JCP.29267
关键词: SOX2 、 Prostate cancer 、 Stem cell 、 Biology 、 LNCaP 、 Cancer research 、 Cell growth 、 Gene knockdown 、 Tumor progression 、 Enzalutamide
摘要: … We determined that elevating SOX2 failed to block the ability of enzalutamide to reduce the expression of PSA (Figure 6a). More specifically, the reduction in PSA expression in the …
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