Sox2 is involved in paclitaxel resistance of the prostate cancer cell line PC-3 via the PI3K/Akt pathway.
作者： DONG LI , LI-NAN ZHAO , XIU-LAN ZHENG , PING LIN , FENG LIN
关键词:
摘要: Prostate cancer is the most commonly diagnosed type of and second leading cause cancer‑associated mortality in males. The efficacy prostate chemotherapy frequently impaired by drug resistance; however, underlying mechanisms this resistance remain elusive. Sex determining region Y-box 2 (Sox2) vital importance regulation stem cell proliferation carcinogenesis. In present study, using MTT, clone formation, cycle apoptosis assays, over-expression Sox2 was demonstrated to enhance paclitaxel (Pac) PC-3 line, promoting exhibiting an anti‑apoptotic effect. Western blot analysis revealed that phosphoinositide 3-kinase/Akt signaling pathway activated cells overexpressing Sox2, targeting cyclin E survivin, promoted G1/S phase transition prevented under Pac treatment. study provided understanding may indicate novel therapeutic methods for chemoresistant cancer.
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