Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer.

摘要: Serological analysis of expression cDNA libraries (SEREX) derived from two small cell lung cancer (SCLC) lines using pooled sera SCLC patients led to the isolation 14 genes, including 4 SOX group B genes (SOX1, SOX2, SOX3, and SOX21) ZIC2. ZIC2 encode DNA-binding proteins; proteins regulate transcription target in presence cofactors, whereas is also suspected be a transcriptional regulator. These are expressed at early developmental stages embryonic nervous system, but down-regulated adult. Although SOX2 mRNA can detected some adult tissues, only brain testis, SOX1, SOX21 transcripts not detectable normal tissues. Of tested, 80% mRNA, SOX3 was 40%, 50%, 10%, respectively. antigens elicited serological responses 30–40% this series, titers up 1:106. In 23 adults, no antibody against or except for one individual with low-titer anti-SOX2 antibody. Seroreactivity SOX1 2 consistently higher titered than 21 reactivity, suggesting and/or as main eliciting anti-SOX responses. paraneoplastic neurological syndromes have been associated several antigens, symptoms observed anti-ZIC2 antibodies.