Downregulation of HMGA2 inhibits cellular proliferation and invasion, improves cellular apoptosis in prostate cancer

摘要: Prostate cancer is the most commonly diagnosed among men and second leading cause of cancer-associated deaths in world. Unfortunately, treatment failures are common due to metastasis chemoresistance, but underlying molecular mechanism remains unclear. Accumulating evidence has indicated that deregulation DNA-binding protein High Mobility Group A2 (HMGA2) associated with development progression cancer. This study aimed explore expression HMGA2 prostate tissues its correlation clinical pathology cancer, discuss role The results showed messenger RNA (mRNA) cells was significantly higher than normal (p < 0.05), positive rate mRNA from patients lymph node or high Gleason grade negative low (p < 0.05). In order human PC3 cell line downregulated by interference. Then, changes proliferation, apoptosis, invasion, migration were examined MTT test, PI staining, Annexin V-FITC Transwell chamber assay. Results abilities suppressed knockdown cells, apoptosis enhanced cells. cyclin A vimentin caspase 3 E-cadherin upregulated Taken together, overexpression might be related tumorigenesis, downregulation could inhibit cellular metastasis, improve which a potential target for