Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines

摘要: Ubiquitin C-terminal hydrolase-L3 (UCH-L3) is among the deubiquitinating enzymes (DUBs) that cleave ubiquitin (Ub) from Ub precursors or protein substrates. Many DUBs have been shown to participate in cancer progression various tissues. However, mechanism and role of UCH-L3 carcinogenesis has largely unknown until recently. Here we investigated implication prostate progression. Interestingly, upregulated normal non-metastatic cells downregulated metastatic cell lines. Notably, knockdown line RWPE1 promotes epithelial-to-mesenchymal transition (EMT), an important process for invasion metastasis. The induction EMT by results increase migration invasion. Yet, contrary, overexpression highly PC3 reverses but active site mutant did not. Collectively, our findings identify as a novel regulator highlight potential therapeutic target preventing cancer.