Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications

摘要: Protein ubiquitination and deubiquitination participate in a number of biological processes, including cell growth, differentiation, transcriptional regulation, oncogenesis. Ubiquitin C-terminal hydrolases (UCHs), subfamily deubiquitinating enzymes (DUBs), includes four members: UCH-L1/PGP9.5 (protein gene product 9.5), UCH-L3, UCHL5/UCH37, BRCA1-associated protein-1 (BAP1). Recently, more attention has been paid to the relationship between UCH family malignancies, which play different roles progression tumors. It remains controversial whether UCHL1 is tumor promoter or suppressor. UCHL3 UCH37 are considered be promoters, while BAP1 Studies have showed that influence several signaling pathways crucial oncogenesis, invasion, migration. In addition, families associated with sensitivity therapeutic modalities. Here, we reviewed development tumors, highlighting potential consideration as new interesting targets for anticancer drugs.