Mutation Profiling in Cholangiocarcinoma: Prognostic and Therapeutic Implications

作者: Chaitanya R. Churi , Rachna Shroff , Ying Wang , Asif Rashid , HyunSeon C. Kang

DOI: 10.1371/JOURNAL.PONE.0115383

关键词: CDKN2AMetastasisOncologyKRASInternal medicineBioinformaticsPBRM1BAP1Breast cancerARID1AIDH1Medicine

摘要: … with KRAS wt on erlotinib. Two cases with sustained stable disease are illustrated in Fig. 9. … IDH1 (R132C) mutations represented a significant number of cases that may be potentially …

参考文章(44)
Kurt Schalper, Xabier de Aretxabala, Chaitanya Churi, Iván Roa, Gonzalo de Toro, Milind Javle, Overexpression of the HER2/neu Gene: A New Therapeutic Possibility for Patients With Advanced Gallbladder Cancer. Gastrointestinal cancer research : GCR. ,vol. 7, pp. 42- 48 ,(2014)
Ishwaria M Subbiah, Vivek Subbiah, Apostolia M Tsimberidou, Aung Naing, Ahmed O Kaseb, Milind Javle, Siqing Fu, David S Hong, Sarina Piha-Paul, Jennifer J Wheler, Kenneth R Hess, Filip Janku, Gerald S Falchook, Robert A Wolff, Razelle Kurzrock, None, Targeted Therapy of Advanced Gallbladder Cancer and Cholangiocarcinoma with Aggressive Biology: Eliciting Early Response Signals from Phase 1 trials Oncotarget. ,vol. 4, pp. 153- 162 ,(2013) , 10.18632/ONCOTARGET.832
Yasser Shaib, Hashem El-Serag, The epidemiology of cholangiocarcinoma. Seminars in Liver Disease. ,vol. 24, pp. 115- 125 ,(2004) , 10.1055/S-2004-828889
Christopher J. Pirozzi, Zachary J. Reitman, Hai Yan, Releasing the Block: Setting Differentiation Free with Mutant IDH Inhibitors Cancer Cell. ,vol. 23, pp. 570- 572 ,(2013) , 10.1016/J.CCR.2013.04.024
Rashmi Kanagal-Shamanna, Bryce P Portier, Rajesh R Singh, Mark J Routbort, Kenneth D Aldape, Brian A Handal, Hamed Rahimi, Neelima G Reddy, Bedia A Barkoh, Bal M Mishra, Abhaya V Paladugu, Jawad H Manekia, Neda Kalhor, Sinchita Roy Chowdhuri, Gregg A Staerkel, L Jeffrey Medeiros, Rajyalakshmi Luthra, Keyur P Patel, Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagnostics Modern Pathology. ,vol. 27, pp. 314- 327 ,(2014) , 10.1038/MODPATHOL.2013.122
Susumu Yamasaki, Intrahepatic cholangiocarcinoma: macroscopic type and stage classification. Journal of Hepato-biliary-pancreatic Surgery. ,vol. 10, pp. 288- 291 ,(2003) , 10.1007/S00534-002-0732-8
Jeffrey A Engelman, Liang Chen, Xiaohong Tan, Katherine Crosby, Alexander R Guimaraes, Rabi Upadhyay, Michel Maira, Kate McNamara, Samanthi A Perera, Youngchul Song, Lucian R Chirieac, Ramneet Kaur, Angela Lightbown, Jessica Simendinger, Timothy Li, Robert F Padera, Carlos García-Echeverría, Ralph Weissleder, Umar Mahmood, Lewis C Cantley, Kwok-Kin Wong, Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers Nature Medicine. ,vol. 14, pp. 1351- 1356 ,(2008) , 10.1038/NM.1890
Yuchen Jiao, Timothy M Pawlik, Robert A Anders, Florin M Selaru, Mirte M Streppel, Donald J Lucas, Noushin Niknafs, Violeta Beleva Guthrie, Anirban Maitra, Pedram Argani, G Johan A Offerhaus, Juan Carlos Roa, Lewis R Roberts, Gregory J Gores, Irinel Popescu, Sorin T Alexandrescu, Simona Dima, Matteo Fassan, Michele Simbolo, Andrea Mafficini, Paola Capelli, Rita T Lawlor, Andrea Ruzzenente, Alfredo Guglielmi, Giampaolo Tortora, Filippo De Braud, Aldo Scarpa, William Jarnagin, David Klimstra, Rachel Karchin, Victor E Velculescu, Ralph H Hruban, Bert Vogelstein, Kenneth W Kinzler, Nickolas Papadopoulos, Laura D Wood, None, Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas Nature Genetics. ,vol. 45, pp. 1470- 1473 ,(2013) , 10.1038/NG.2813
Rajmohan Murali, Thomas Wiesner, Richard A. Scolyer, Tumours associated with BAP1 mutations. Pathology. ,vol. 45, pp. 116- 126 ,(2013) , 10.1097/PAT.0B013E32835D0EFB
Woonyoung Choi, Sima Porten, Seungchan Kim, Daniel Willis, Elizabeth R. Plimack, Jean Hoffman-Censits, Beat Roth, Tiewei Cheng, Mai Tran, I-Ling Lee, Jonathan Melquist, Jolanta Bondaruk, Tadeusz Majewski, Shizhen Zhang, Shanna Pretzsch, Keith Baggerly, Arlene Siefker-Radtke, Bogdan Czerniak, Colin P.N. Dinney, David J. McConkey, Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy Cancer Cell. ,vol. 25, pp. 152- 165 ,(2014) , 10.1016/J.CCR.2014.01.009