Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

作者: Jeffrey A Engelman , Liang Chen , Xiaohong Tan , Katherine Crosby , Alexander R Guimaraes

DOI: 10.1038/NM.1890

关键词:

摘要: … for the maintenance of established Kras-driven tumors. We used both the tetracycline-inducible Tet-op-Kras G12D transgenic model 4 as well as the LSL Kras G12D mouse model to …

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