Lack of association between UCHL1 S18Y gene polymorphism and Parkinson’s disease in the Asian population: a meta-analysis

摘要: Although many case–control studies have investigated the association between a single UCHL1 S18Y gene polymorphism and risk of Parkinson’s disease (PD), results been ambiguous. To evaluate overall effect published Asian subjects, we conducted meta-analysis based on 11 including 3,971 PD cases 3,721 controls. Studies carried out up to 30 April 2014, were identified using databases PubMed, MEDLINE, EMBASE Web Knowledge. The crude odds ratios (ORs) with 95 % confidence intervals (95 CI) calculated association. our indicated that does not correlate (allele model: OR 0.93, CI 0.84–1.02; dominant 0.94, 0.86–1.04; recessive 0.90, 0.77–1.06; homozygous 0.86, 0.71–1.04). A similar result was observed in subgroup analysis ethnicity, age at onset, genotype methods, Hardy–Weinberg equilibrium, source Thus, current suggests no evidence for population, especially subgroups ethnicity onset. Further larger population sizes are needed confirm this result.