Skp2 is associated with paclitaxel resistance in prostate cancer cells
作者： YEGUO YANG , YI LU , LIHUI WANG , ATSUSHI MIZOKAMI , EVAN T. KELLER
DOI: 10.3892/OR.2016.4809
关键词: Internal medicine 、 Oncology 、 Oncogene 、 Cancer stem cell 、 Cancer research 、 Cancer 、 SKP2 、 DU145 、 Prostate cancer 、 Paclitaxel 、 Biology 、 Cell cycle
摘要: Prostate cancer is the most commonly diagnosed tumor in men United States. Patients with hormone-refractory prostate are often treated paclitaxel, but of them eventually develop drug resistance. S-phase kinase associated protein 2 (Skp2) a component SCF (Skp1-Cullin1-F-box) type E3 ubiquitin ligase complexes. In present study, we investigated role Skp2 paclitaxel-resistant DU145-TxR or PC-3-TxR cells by silencing using inhibitors. We first confirmed that expression up-regulated compared their parental DU145 PC-3, respectively. Knockdown inhibitor treatment restored paclitaxel sensitivity. E-cadherin was decreased while Vimentin increased cells. addition, p27 inversely correlated Moreover, found to increase both and These results suggest cell resistance paclitaxel. may be potential therapeutic target for drug-resistant cancer.
sci-hub.se 参考文章(33)
Zuzana Pernicová, Eva Slabáková, Gvantsa Kharaishvili, Jan Bouchal, Milan Král, Zuzana Kunická, Miroslav Machala, Alois Kozubík, Karel Součcek, Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2 Neoplasia. ,vol. 13, pp. 526- 536 ,(2011) , 10.1593/NEO.11182
Malgorzata Statkiewicz, Natalia Maryan, Agnieszka Lipiec, Emilia Grecka, Monika A. Grygorowicz, Marcin Omiotek, Agnieszka Gorska, Michal Mikula, Maciej Malecki, The role of the SHH
gene in prostate cancer cell resistance to paclitaxel The Prostate. ,vol. 74, pp. 1142- 1152 ,(2014) , 10.1002/PROS.22830
Yi-Fan Zhao, Jing-Yu Zhao, Hong Yue, Ke-Shi Hu, Hao Shen, Zheng-Gang Guo, Xiao-Jun Su, FOXD1 promotes breast cancer proliferation and chemotherapeutic drug resistance by targeting p27 Biochemical and Biophysical Research Communications. ,vol. 456, pp. 232- 237 ,(2015) , 10.1016/J.BBRC.2014.11.064
Tuong Vy Thi Le, Youngcheol Seo, Chun Jeih Ryu, Hye Ran Lee, Hyun-Ju Park, Increased expression of p27 is associated with the cisplatin resistance in gastric cancer cell line YCC-3 Archives of Pharmacal Research. ,vol. 33, pp. 1127- 1132 ,(2010) , 10.1007/S12272-010-0720-5
Chia-Hsin Chan, John Kenneth Morrow, Shuxing Zhang, Hui-Kuan Lin, Skp2: a dream target in the coming age of cancer therapy. Cell Cycle. ,vol. 13, pp. 679- 680 ,(2014) , 10.4161/CC.27853
Ofer Ben-Izhak, Shirly Lahav-Baratz, Shimon Meretyk, Shoshana Ben-Eliezer, Edmond Sabo, Martha Dirnfeld, Shai Cohen, Aaron Ciechanover, Inverse Relationship Between Skp2 Ubiquitin Ligase and the Cyclin Dependent Kinase Inhibitor p27Kip1 in Prostate Cancer The Journal of Urology. ,vol. 170, pp. 241- 245 ,(2003) , 10.1097/01.JU.0000072113.34524.A7
YouQiang Li, Atsushi Mizokami, Kouji Izumi, Kazutaka Narimoto, Takashi Shima, Jian Zhang, Jinlu Dai, Evan T. Keller, Mikio Namiki, CTEN/tensin 4 expression induces sensitivity to paclitaxel in prostate cancer. The Prostate. ,vol. 70, pp. 48- 60 ,(2010) , 10.1002/PROS.21037
Yuting Sun, Bu-Er Wang, Kevin G. Leong, Peng Yue, Li Li, Suchit Jhunjhunwala, Darrell Chen, Kyounghee Seo, Zora Modrusan, Wei-Qiang Gao, Jeffrey Settleman, Leisa Johnson, Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer Research. ,vol. 72, pp. 527- 536 ,(2012) , 10.1158/0008-5472.CAN-11-3004
Q Yang, J Huang, Q Wu, Y Cai, L Zhu, X Lu, S Chen, C Chen, Z Wang, Acquisition of epithelial-mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells. British Journal of Cancer. ,vol. 110, pp. 1958- 1967 ,(2014) , 10.1038/BJC.2014.136
Hongling Zhao, Frederick Bauzon, Hao Fu, Zhonglei Lu, Jinhua Cui, Keiko Nakayama, Keiich I. Nakayama, Joseph Locker, Liang Zhu, Skp2 Deletion Unmasks a p27 Safeguard that Blocks Tumorigenesis in the Absence of pRb and p53 Tumor Suppressors Cancer Cell. ,vol. 24, pp. 645- 659 ,(2013) , 10.1016/J.CCR.2013.09.021