Skp2 Deletion Unmasks a p27 Safeguard that Blocks Tumorigenesis in the Absence of pRb and p53 Tumor Suppressors
作者： Hongling Zhao , Frederick Bauzon , Hao Fu , Zhonglei Lu , Jinhua Cui
DOI: 10.1016/J.CCR.2013.09.021
关键词: Retinoblastoma protein 、 Ubiquitin-Protein Ligases 、 Ubiquitin 、 Carcinogenesis 、 Ubiquitin ligase 、 DNA replication 、 Pituitary neoplasm 、 SKP2 、 Biology 、 Cancer research
摘要: pRb and p53 are two major tumor suppressors. Here, we found that activates expression of Pirh2 KPC1, the three ubiquitin ligases for p27. Loss in absence Skp2, third ligase p27, shrinks cellular pool p27 to accumulate protein. In p53, was unable inhibit DNA synthesis spite its abundance, but could division cells maintain replication with rereplication. This mechanism blocked pRb/p53 doubly deficient pituitary prostate tumorigenesis lastingly coexistent bromodeoxyuridine-labeling neoplastic lesions, revealing an unconventional cancer cell vulnerability when inactivated.
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