Roles of sex-determining region Y-box 2 in cell pluripotency and tumor-related signaling pathways.
作者： JINGJIE WANG , HUIJUAN ZENG , HANJUN LI , JUANJUAN ZHANG , SHAOHUA WANG
DOI: 10.3892/MCO.2015.639
关键词:
摘要: The sex-determining region Y-box 2 (SOX2) gene, a member of the Sry-like high-mobility group box (SOX) gene family, encodes transcription factor Sox2, which significantly contributes to regulation cell pluripotency. Sox2 is closely associated with early embryonic development, neural differentiation and other biological processes. An inreasing number recent studies suggest that exerts positive effect on malignant tumors. According these results, expected become novel target for cancer therapy by unveiling mechanism through it affects behavior Therefore, crucial elucidate detailed association aim this study was review role in pluripotency maintenance, development differentiation, as well investigate regulates stem cells tumorigenesis.
sci-hub.se 参考文章(43)
Yue Zhang, Xiaoyun Chen, Xiao Ou Mao, Renyu Lin, Yi Zhu, Li Wan, He Li, Huxiang Zhang, Jianfu Chen, Kunlin Jin, Jianhua Peng, Notch1 signaling is activated in cells expressing embryonic stem cell proteins in human primary nasopharyngeal carcinoma. Journal of Otolaryngology-head & Neck Surgery. ,vol. 39, pp. 157- 166 ,(2010) , 10.2310/7070.2009.090150
Wen‐Tsen Fang, Chi‐Chen Fan, Shih‐Miao Li, Te‐Hsuan Jang, Hsiu‐Ping Lin, Neng‐Yao Shih, Chung‐Hsing Chen, Tao‐Yeuen Wang, Shiu‐Feng Huang, Alan Yueh‐Luen Lee, Ying‐Lan Liu, Fang‐Yu Tsai, Chih‐Ting Huang, Su Jing Yang, Lin‐Ju Yen, Chih‐Pin Chuu, Chih‐Yi Chen, Chao A Hsiung, Jang‐Yang Chang, Lu‐Hai Wang, I‐Shou Chang, Shih Sheng Jiang, None, Downregulation of a putative tumor suppressor BMP4 by SOX2 promotes growth of lung squamous cell carcinoma International Journal of Cancer. ,vol. 135, pp. 809- 819 ,(2014) , 10.1002/IJC.28734
Kenji Mizuseki, Yoshiki Sasai, Shigetada Nakanishi, Masashi Kishi, Masaru Matsui, Xenopus Zic-related-1 and Sox-2, two factors induced by chordin, have distinct activities in the initiation of neural induction Development. ,vol. 125, pp. 579- 587 ,(1998) , 10.1242/DEV.125.4.579
C. Dong, D. Wilhelm, P. Koopman, Sox genes and cancer. Cytogenetic and Genome Research. ,vol. 105, pp. 442- 447 ,(2004) , 10.1159/000078217
Shinji Masui, Yuhki Nakatake, Yayoi Toyooka, Daisuke Shimosato, Rika Yagi, Kazue Takahashi, Hitoshi Okochi, Akihiko Okuda, Ryo Matoba, Alexei A. Sharov, Minoru S. H. Ko, Hitoshi Niwa, Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells Nature Cell Biology. ,vol. 9, pp. 625- 635 ,(2007) , 10.1038/NCB1589
W. Pan, Y. Jin, J. Chen, R. J. Rottier, K. P. Steel, A. E. Kiernan, Ectopic Expression of Activated Notch or SOX2 Reveals Similar and Unique Roles in the Development of the Sensory Cell Progenitors in the Mammalian Inner Ear The Journal of Neuroscience. ,vol. 33, pp. 16146- 16157 ,(2013) , 10.1523/JNEUROSCI.3150-12.2013
NING YANG, LIAN HUI, YAN WANG, HUIJUN YANG, XUEJUN JIANG, SOX2 promotes the migration and invasion of laryngeal cancer cells by induction of MMP-2 via the PI3K/Akt/mTOR pathway. Oncology Reports. ,vol. 31, pp. 2651- 2659 ,(2014) , 10.3892/OR.2014.3120
Chun Sun, Lu Sun, Yan Li, Xiaonan Kang, Shu Zhang, Yinkun Liu, Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating Slug. Medical Oncology. ,vol. 30, pp. 503- ,(2013) , 10.1007/S12032-013-0503-1
DONG LI, LI-NAN ZHAO, XIU-LAN ZHENG, PING LIN, FENG LIN, YUE LI, HAI-FENG ZOU, RONG-JUN CUI, HUI CHEN, XIAO-GUANG YU, Sox2 is involved in paclitaxel resistance of the prostate cancer cell line PC-3 via the PI3K/Akt pathway. Molecular Medicine Reports. ,vol. 10, pp. 3169- 3176 ,(2014) , 10.3892/MMR.2014.2630
Shuchen Zhang, Sox2, a key factor in the regulation of pluripotency and neural differentiation World Journal of Stem Cells. ,vol. 6, pp. 305- 311 ,(2014) , 10.4252/WJSC.V6.I3.305