Mucin glycosylation is altered by pro-inflammatory signaling in pancreatic-cancer cells.
作者： Yi-Mi Wu , D. David Nowack , Gilbert S. Omenn , Brian B. Haab
DOI: 10.1021/PR8008379
关键词: Glycosylation 、 Biology 、 Proinflammatory cytokine 、 Signal transduction 、 Biochemistry 、 Tumor necrosis factor alpha 、 Pancreatic cancer 、 MUC1 、 Cancer 、 Cell biology 、 Mucin
摘要: Altered glycosylation on the surfaces or secreted proteins of tumor cells is common in pancreatic cancer and thought to promote progression, but factors leading changes carbohydrate structures are incompletely understood. We hypothesized that pro-inflammatory conditions can lead alterations cancer-associated glycans mucins produced by pancreatic-cancer cells. With use a novel antibody-glycan microarray method, we measured effects stimuli (oxidative stress treatment with cytokines IFNγ, IL-1α, TNFα) expression MUC1, MUC5AC, MUC16 multiple cell lines. Mucin was significantly affected specific lines, particularly involving terminal galactose N-acetylgalactosamine. In addition, responses lines grouped according cell-surface markers associated tumorigenicity, as bearing min...
acs.org
andrews.edu
core.ac.uk 参考文章(56)
Barry J. Campbell, Lu-Gang Yu, Jonathan M. Rhodes, Altered glycosylation in inflammatory bowel disease: A possible role in cancer development Glycoconjugate Journal. ,vol. 18, pp. 851- 858 ,(2001) , 10.1023/A:1022240107040
Philippe Roussel, Jean-Marc Périni, Philippe Delmotte, Sophie Degroote, Marc D. Merten, Isabelle Van Seuningen, Annie Bernigaud, Catherine Figarella, Influence of TNFalpha on the sialylation of mucins produced by a transformed cell line MM-39 derived from human tracheal gland cells. Glycoconjugate Journal. ,vol. 18, pp. 487- 497 ,(2001) , 10.1023/A:1016038219183
Francis W. Luscinskas, Geoffrey Scott Kansas, Amy J. Wagers, Yaw Chyn Lim, Andrew H. Lichtman, Lori Henault, Expression of Functional Selectin Ligands on Th Cells Is Differentially Regulated by IL-12 and IL-4 Journal of Immunology. ,vol. 162, pp. 3193- 3201 ,(1999)
K Maemura, M Fukuda, Poly-N-acetyllactosaminyl O-glycans attached to leukosialin. The presence of sialyl Le(x) structures in O-glycans. Journal of Biological Chemistry. ,vol. 267, pp. 24379- 24386 ,(1992) , 10.1016/S0021-9258(18)35777-6
Martin E. Lidell, Jacques Bara, Gunnar C. Hansson, Mapping of the 45M1 epitope to the C-terminal cysteine-rich part of the human MUC5AC mucin. FEBS Journal. ,vol. 275, pp. 481- 489 ,(2008) , 10.1111/J.1742-4658.2007.06215.X
Osamu Hasebe, Kazuhisa Shimodaira, Tsutomu Katsuyama, Jun Nakayama, Naoshi Nakamura, Minoru Fukuda, Carcinoma-associated Expression of Core 2 β-1,6-N-Acetylglucosaminyltransferase Gene in Human Colorectal Cancer: Role of O-Glycans in Tumor Progression Cancer Research. ,vol. 57, pp. 5201- 5206 ,(1997)
Lisa M. Coussens, Zena Werb, Inflammation and cancer Nature. ,vol. 420, pp. 860- 867 ,(2002) , 10.1038/NATURE01322
Michael D. Burdick, Ann Harris, Colm J. Reid, Takeshi Iwamura, Michael A. Hollingsworth, Oligosaccharides Expressed on MUC1 Produced by Pancreatic and Colon Tumor Cell Lines Journal of Biological Chemistry. ,vol. 272, pp. 24198- 24202 ,(1997) , 10.1074/JBC.272.39.24198
N Moniaux, M Andrianifahanana, R E Brand, S K Batra, Multiple roles of mucins in pancreatic cancer, a lethal and challenging malignancy. British Journal of Cancer. ,vol. 91, pp. 1633- 1638 ,(2004) , 10.1038/SJ.BJC.6602163
M Andrianifahanana, A P Singh, C Nemos, M P Ponnusamy, N Moniaux, P P Mehta, G C Varshney, S K Batra, IFN-gamma-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: a novel mechanism for IFN-gamma response. Oncogene. ,vol. 26, pp. 7251- 7261 ,(2007) , 10.1038/SJ.ONC.1210532