Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use

摘要: The present invention relates to Fc region-containing polypeptides that exhibit improved effector function due alterations of the extent fucosylation, and methods using such for treating or preventing cancer other diseases. are preferably immunoglobulins (e.g., antibodies), in which region comprises at least one amino acid substitution relative corresponding sequence a wild type region, is sufficient attenuate post-translational fucosylation mediate binding an activating receptor reduced inhibitory receptor. particularly useful preventing, treating, ameliorating more symptoms associated with disease, disorder, infection where either enhanced efficacy cell mediated by FcγR desired cancer, infectious disease) inhibited response inflammation, autoimmune disease).