Novel therapeutic treatments with anti-her2 antibodies having a low fucosylation
作者： Antje Danielczyk , Steffen Goletz
DOI:
关键词:
摘要: The present invention pertains to the field of cancer therapy using anti-cancer antibodies. medical use anti-HER2 antibodies having improved glycosylation characteristics, in particular a reduced fucosylation, is provided which show enhanced efficacy.
google.nl 参考文章(16)
Lore Florin, Hitto Kaufmann, Kristina Ellwanger, Production of low fucose antibodies in h4-ii-e rat cells ,(2011)
Emmanuel Nony, Christophe de Romeuf, Philippe Klein, Christine Gaucher, Sylvie Jorieux, Nicolas Bihoreau, Dominique Bourel, Use of adcc-optimized antibodies for treating weak patients ,(2004)
Sergey Gorlatov, Godfrey Jonah Anderson Rainey, Leslie S. Johnson, Laura Lerner, Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use ,(2010)
Eiji Suzuki, Rinpei Niwa, Shigehira Saji, Mariko Muta, Makiko Hirose, Shigeru Iida, Yukimasa Shiotsu, Mitsuo Satoh, Kenya Shitara, Masahide Kondo, Masakazu Toi, A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients Clinical Cancer Research. ,vol. 13, pp. 1875- 1882 ,(2007) , 10.1158/1078-0432.CCR-06-1335
Tillman U. Gerngross, Methods for producing modified glycoproteins ,(2001)
Toyohide Shinkawa, Emi Shoji, Nobuo Hanai, Susumu Imabeppu, Hideharu Anazawa, Naoko Yamane, Kazuyasu Nakamura, Motoo Yamasaki, Yutaka Kanda, Kazuhisa Uchida, Method for controlling the activity of immunologically functional molecule ,(2000)
Teemu T. Junttila, Kathryn Parsons, Christine Olsson, Yanmei Lu, Yan Xin, Julie Theriault, Lisa Crocker, Oliver Pabonan, Tomasz Baginski, Gloria Meng, Klara Totpal, Robert F. Kelley, Mark X. Sliwkowski, Superior In vivo Efficacy of Afucosylated Trastuzumab in the Treatment of HER2-Amplified Breast Cancer Cancer Research. ,vol. 70, pp. 4481- 4489 ,(2010) , 10.1158/0008-5472.CAN-09-3704
Antje Danielczyk, Renate Stahn, Steffen Goletz, Lars Stöckl, Hans Baumeister, Anja Löffler, Use of human cells of myeloid leukaemia origin for expression of antibodies ,(2007)
Leonard G. Presta, Polypeptide variants with altered effector function ,(2000)
Alessandra Beano, Elena Signorino, Andrea Evangelista, Davide Brusa, Marinella Mistrangelo, Maria Polimeni, Rosella Spadi, Michela Donadio, Libero Ciuffreda, Lina Matera, Correlation between NK function and response to trastuzumab in metastatic breast cancer patients Journal of Translational Medicine. ,vol. 6, pp. 25- 25 ,(2008) , 10.1186/1479-5876-6-25