Use of adcc-optimized antibodies for treating weak patients
作者： Emmanuel Nony , Christophe de Romeuf , Philippe Klein , Christine Gaucher , Sylvie Jorieux
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摘要: The invention concerns the use of human or humanized chimeric monoclonal antibodies which are produced in selected cell lines, said bringing about a high ADCC activity as well secretion cytokines and interleukins, for treating underpopulations so-called weak-response patients exhibiting CD16 FCGR3A-158F homozygote FCGR3A-158V/F heterozygote polymorphism.
lens.org参考文章(74)
Philippe Klein, Roland Béliard, Arnaud Glacet, Sébastien Moitel, Thierry Ducrot, Dominique Bourel, Human recombinant anti-Rh(D) monoclonal antibodies: Improvement of biological properties by in vitro class-switch Human antibodies. ,vol. 8, pp. 17- 25 ,(1997) , 10.3233/HAB-1997-8103
Rinpei Niwa, Kenya Shitara, Shigeki Hatanaka, Kazuyasu Nakamura, Akira Okazaki, Therapeutic agent for patients having human FcgammaRIIIa ,(2003)
Jan Fisher, Michael W. Fanger, Paul K. Wallace, Yashwant M. Deo, Robert F. Graziano, Tibor Keler, Paul M. Guyre, Aditya Mandal, Bispecific antibody-dependent cellular cytotoxicity of HER2/neu-overexpressing tumor cells by Fc gamma receptor type I-expressing effector cells. Cancer Research. ,vol. 57, pp. 4008- 4014 ,(1997)
T Goto, SJ Kennel, M Abe, M Takishita, M Kosaka, A Solomon, S Saito, A novel membrane antigen selectively expressed on terminally differentiated human B cells Blood. ,vol. 84, pp. 1922- 1930 ,(1994) , 10.1182/BLOOD.V84.6.1922.1922
Pablo Umaña, Joël Jean–Mairet, Radmila Moudry, Hanspeter Amstutz, James E. Bailey, Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity Nature Biotechnology. ,vol. 17, pp. 176- 180 ,(1999) , 10.1038/6179
BM Kumpel, MJ Goodrick, DH Pamphilon, ID Fraser, GD Poole, C Morse, GR Standen, GE Chapman, DP Thomas, DJ Anstee, Human Rh D Monoclonal Antibodies (BRAD-3 and BRAD-5) Cause Accelerated Clearance of Rh D+ Red Blood Cells and Suppression of Rh D Immunization in Rh D- Volunteers Blood. ,vol. 86, pp. 1701- 1709 ,(1995) , 10.1182/BLOOD.V86.5.1701.BLOODJOURNAL8651701
Sherie L. Morrison, Ann Wright, Effect of C2-Associated Carbohydrate Structure on Ig Effector Function: Studies with Chimeric Mouse-Human IgG1 Antibodies in Glycosylation Mutants of Chinese Hamster Ovary Cells Journal of Immunology. ,vol. 160, pp. 3393- 3402 ,(1998)
Philip Babcock Gove, Webster's third new international dictionary of the English language, unabridged ,(1971)
Dominique Goossens, Françoise Champomier, Philippe Rouger], Charles Salmon, Human monoclonal antibodies against blood group antigens Journal of Immunological Methods. ,vol. 101, pp. 193- 200 ,(1987) , 10.1016/0022-1759(87)90150-5
Jean‐Luc D'hautcourt, Quantitative Flow Cytometric Analysis of Membrane Antigen Expression Current Protocols in Cytometry. ,vol. 22, ,(2002) , 10.1002/0471142956.CY0612S22