Behavioural and biochemical effects of haloperidol during the oestrous cycle of the rat.

摘要: The effects of two doses (1 and 2 mg/kg, i.p.) haloperidol (HAL) on catalepsy, concentrations DA DOPAC in frontal cortex, nucleus accumbens striatum serum levels oestradiol were investigated intact female rats during the 4-day oestrous cycle. Catalepsy induced by did not vary much phases turnover cortex was significantly greater proestrus smaller oestrus. effect marginally affected cycle being greatest higher lower No significant differences detected between diestrus metestrus. After there a dramatic increase oestrus, slight metestrus decrease proestrus. However, different treated with haloperidol. results indicate that has detectable influence DAergic mechanisms possibly tuberoinfudibular system, brought about treatment