Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes

摘要: Thyroid hormone excess has potentially useful effects, including lowering of serum cholesterol and reduction body fat. However, the therapeutic application this so far been hampered by deleterious effects on heart, muscle bone. This article reviews recent progress in development selective thyroid mimetics that seem to lack adverse actions associated with itself, making them a promising new strategy for treatment atherosclerosis, obesity type 2 diabetes. hormones influence heart rate, lipids, metabolic weight multiple aspects lipid, carbohydrate, protein mineral metabolism. Although increased levels can improve lipid profiles reduce fat, these positive are counterbalanced harmful Thus, attempts use cholesterol-lowering loss purposes have limited. over past decade, analogues capable uncoupling beneficial from developed. Such drugs could serve as powerful tools address two largest medical problems developed countries — atherosclerosis obesity.