Pharmaceutical compositions and preparations for treatment of metabolic bone disease

摘要: The present invention relates to a pharmaceutical composition for the treatment of metabolic bone disease and method preparation thereof, more particularly, an improved therapeutic wherein said is prepared as composite agent which comprises calcitriol; reduces rate spine fractures increases density; alendronate, resorption inhibitor, two main active ingredients in optimal mixing ratio exert greatest synergistic effect; adequate amount other additives such fortifier alendronate. Therefore, according can inhibit hypercalcemia caused when administered by calcitriol alone, compensate inhibitory activity remodeling alendronate due presence calcitriol, improve drug compliance associated with usual difficulty administration well side effect esophagus, thus effectively preventing occurence osteoporosis.