Molecular epidemiological analysis of three hepatitis C virus outbreaks in Jammu and Kashmir State, India.

作者: Sanjim Chadha , Uma Sharma , Artee Chaudhary , Charu Prakash , Sunil Gupta

DOI: 10.1099/JMM.0.000284

关键词: Hepatitis C virusEpidemiologyHepatitis COutbreakBiologyTransmission (medicine)Molecular epidemiologyDisease clusterVirologyHepacivirus

摘要: Outbreaks of hepatitis C virus (HCV) infection are associated with unsafe injection practices, intravenous drug abuse and other exposure to blood body fluids. We report here three outbreaks HCV from Jammu Kashmir (JK a total 115 samples were sent the NCDC for RT-PCR, 77 positive. Subtype 3a was found in all Anantnag (February 2013); subtype 3b, Srinagar (May 2015). Subtypes 3g identified two Kulgam outbreak (July 2014). A detailed epidemiological investigation should be conducted whenever cluster cases is revealed, as this potentially allows identification larger outbreaks. Epidemiological investigations further supported by inclusion molecular tests. Efforts limit therapeutic injections only those having strong medical/surgical indications restrict use non-sterile needles essential prevent transmission HCV.

参考文章(48)
N Leone, M Rizzetto, Natural history of hepatitis C virus infection: from chronic hepatitis to cirrhosis, to hepatocellular carcinoma. Minerva gastroenterologica e dietologica. ,vol. 51, pp. 31- 46 ,(2005)
Tripurari Kumar, Aakash Shrivastava, Anil Kumar, Kayla F. Laserson, Jai P. Narain, Srinivasaraghavan Venkatesh, Lakhbir S. Chauhan, Francisco Averhoff, Viral Hepatitis Surveillance--India, 2011-2013. Morbidity and Mortality Weekly Report. ,vol. 64, pp. 758- 762 ,(2015) , 10.15585/MMWR.MM6428A3
Tetsuro Suzuki, Hideki Aizaki, Kyoko Murakami, Ikuo Shoji, Takaji Wakita, Molecular biology of hepatitis C virus. Journal of Gastroenterology. ,vol. 42, pp. 411- 423 ,(2007) , 10.1007/S00535-007-2030-3
A Chakravarti, A Ashraf, S Malik, A study of changing trends of prevalence and genotypic distribution of hepatitis C virus among high risk groups in North India. Indian Journal of Medical Microbiology. ,vol. 31, pp. 354- 359 ,(2013) , 10.4103/0255-0857.118877
N. Kato, M. Hijikata, Y. Ootsuyama, M. Nakagawa, S. Ohkoshi, T. Sugimura, K. Shimotohno, Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 9524- 9528 ,(1990) , 10.1073/PNAS.87.24.9524
Masao Honda, Li-Hua Ping, Rene C.A. Rijnbrand, Elizabeth Amphlett, Berwyn Clarke, David Rowlands, Stanley M. Lemon, Structural Requirements for Initiation of Translation by Internal Ribosome Entry within Genome-Length Hepatitis C Virus RNA Virology. ,vol. 222, pp. 31- 42 ,(1996) , 10.1006/VIRO.1996.0395
C.L. van der Poel, H.W. Reesink, J.J.P. van Boven, H.T.M. Cuypers, I. Winkel, P.J. Exel-Oehlers, W. Schaasberg, P.N. Lelie, A.J. Weiner, A. Polito, S. Quan, R. Di Nello, M. Houghton, D. Mulder-Folkerts, A. Leentvaar-Kuypers, Confirmation of hepatitis C virus infection by new four-antigen recombinant immunoblot assay The Lancet. ,vol. 337, pp. 317- 319 ,(1991) , 10.1016/0140-6736(91)90942-I
DishaA Patel, PravegA Gupta, DeepaM Kinariwala, HetalS Shah, GrishmaR Trivedi, MahendraM Vegad, An investigation of an outbreak of viral hepatitis B in modasa town, gujarat, India. Journal of Global Infectious Diseases. ,vol. 4, pp. 55- 59 ,(2012) , 10.4103/0974-777X.93762